Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines
Coronavirus disease 2019 (COVID-19) pandemic is a serious threat to global public health and social and economic development. Various vaccine platforms have been developed rapidly and unprecedentedly, and at least 16 vaccines receive emergency use authorization (EUA). However, the causative pathogen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.771242/full |
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| author | Yandi Zhang Jo-Lewis Banga Ndzouboukou Mengze Gan Xiaosong Lin Xionglin Fan |
| author_facet | Yandi Zhang Jo-Lewis Banga Ndzouboukou Mengze Gan Xiaosong Lin Xionglin Fan |
| author_sort | Yandi Zhang |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) pandemic is a serious threat to global public health and social and economic development. Various vaccine platforms have been developed rapidly and unprecedentedly, and at least 16 vaccines receive emergency use authorization (EUA). However, the causative pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has continued to evolve and mutate, emerging lots of viral variants. Several variants have successfully become the predominant strains and spread all over the world because of their ability to evade the pre-existing immunity obtained after previous infections with prototype strain or immunizations. Here, we summarized the prevalence and biological structure of these variants and the efficacy of currently used vaccines against the SARS-CoV-2 variants to provide guidance on how to design vaccines more rationally against the variants. |
| first_indexed | 2024-12-23T03:08:05Z |
| format | Article |
| id | doaj.art-b58f191aff914f5eb4c8f384750a530c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T03:08:05Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b58f191aff914f5eb4c8f384750a530c2022-12-21T18:02:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-11-011210.3389/fimmu.2021.771242771242Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used VaccinesYandi ZhangJo-Lewis Banga NdzouboukouMengze GanXiaosong LinXionglin FanCoronavirus disease 2019 (COVID-19) pandemic is a serious threat to global public health and social and economic development. Various vaccine platforms have been developed rapidly and unprecedentedly, and at least 16 vaccines receive emergency use authorization (EUA). However, the causative pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has continued to evolve and mutate, emerging lots of viral variants. Several variants have successfully become the predominant strains and spread all over the world because of their ability to evade the pre-existing immunity obtained after previous infections with prototype strain or immunizations. Here, we summarized the prevalence and biological structure of these variants and the efficacy of currently used vaccines against the SARS-CoV-2 variants to provide guidance on how to design vaccines more rationally against the variants.https://www.frontiersin.org/articles/10.3389/fimmu.2021.771242/fullCOVID-19SARS-CoV-2 variantsvaccine efficacyimmune evasiveepidemiology |
| spellingShingle | Yandi Zhang Jo-Lewis Banga Ndzouboukou Mengze Gan Xiaosong Lin Xionglin Fan Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines Frontiers in Immunology COVID-19 SARS-CoV-2 variants vaccine efficacy immune evasive epidemiology |
| title | Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines |
| title_full | Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines |
| title_fullStr | Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines |
| title_full_unstemmed | Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines |
| title_short | Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines |
| title_sort | immune evasive effects of sars cov 2 variants to covid 19 emergency used vaccines |
| topic | COVID-19 SARS-CoV-2 variants vaccine efficacy immune evasive epidemiology |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.771242/full |
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