Urokinase-loaded cyclic RGD-decorated liposome targeted therapy for in-situ thrombus of pulmonary arteriole of pulmonary hypertension

Urokinase-loaded cyclic RGD-decorated liposome targeted therapy for in-situ thrombus of pulmonary arteriole of pulmonary hypertension

Backgroud:In-situ thrombosis is a significant pathophysiological basis for the development of pulmonary hypertension (PH). However, thrombolytic therapy for in-situ thrombus in PH was often hampered by the apparent side effects and the low bioavailability of common thrombolytic medications. Nanoscal...

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Bibliographic Details
Main Authors: Jingtao Li, Xiaofeng Zhang, Yingying Mo, Tongtong Huang, Huaqing Rao, Zhenyuan Tan, Liuliu Huang, Decai Zeng, Chunlan Jiang, Yanfen Zhong, Yongzhi Cai, Binbin Liang, Ji Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
cyclic RGD peptide
liposome
in-situ thrombus
targeted thrombolysis
pulmonary hypertension
right ventricular function
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.1038829/full

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