Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation

Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation

ABSTRACT Pseudomonas aeruginosa populations evolving in cystic fibrosis lungs, animal hosts, natural environments and in vitro undergo extensive genetic adaption and diversification. A common mutational target is the quorum sensing (QS) system, a three-unit regulatory system that controls the expres...

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Bibliographic Details
Main Authors: Priyanikha Jayakumar, Alexandre R. T. Figueiredo, Rolf Kümmerli
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mSystems
Subjects:
Pseudomonas aeruginosa
evolution
mutation
opportunistic pathogen
quorum sensing
virulence factors
Online Access:https://journals.asm.org/doi/10.1128/msystems.00354-22

Internet

https://journals.asm.org/doi/10.1128/msystems.00354-22

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