Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis.
BACKGROUND: Previous association studies examining the relationship between the APOC1 polymorphism and susceptibility to Alzheimer's disease (AD) have shown conflicting results, and it is not clear if an APOC1 variant acts as a genetic risk factor in AD etiology across multiple populations. MET...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3909044?pdf=render |
| _version_ | 1818250158710718464 |
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| author | Qin Zhou Fan Zhao Ze-ping Lv Chen-guang Zheng Wei-dong Zheng Liang Sun Na-na Wang Shenghang Pang Fabiana Michelsen de Andrade Mian Fu Xiang-hua He Juan Hui WenyYu Jiang Chu-yu Yang Xiao-hong Shi Xiao-quan Zhu Guo-fang Pang Yi-ge Yang Hai-qun Xie Wan-dong Zhang Cai-you Hu Ze Yang |
| author_facet | Qin Zhou Fan Zhao Ze-ping Lv Chen-guang Zheng Wei-dong Zheng Liang Sun Na-na Wang Shenghang Pang Fabiana Michelsen de Andrade Mian Fu Xiang-hua He Juan Hui WenyYu Jiang Chu-yu Yang Xiao-hong Shi Xiao-quan Zhu Guo-fang Pang Yi-ge Yang Hai-qun Xie Wan-dong Zhang Cai-you Hu Ze Yang |
| author_sort | Qin Zhou |
| collection | DOAJ |
| description | BACKGROUND: Previous association studies examining the relationship between the APOC1 polymorphism and susceptibility to Alzheimer's disease (AD) have shown conflicting results, and it is not clear if an APOC1 variant acts as a genetic risk factor in AD etiology across multiple populations. METHODS: To confirm the risk association between APOC1 and AD, we designed a case-control study and also performed a meta-analysis of previously published studies. RESULTS: Seventy-nine patients with AD and one hundred fifty-six unrelated controls were included in case-control study. No association was found between the variation of APOC1 and AD in stage 1 of our study. However, our meta-analysis pooled a total of 2092 AD patients and 2685 controls. The APOC1 rs11568822 polymorphism was associated with increased AD risk in Caucasians, Asians and Caribbean Hispanics, but not in African Americans. APOE ε4 carriers harboring the APOC1 insertion allele, were more prevalent in AD patients than controls (χ(2) = 119.46, OR = 2.79, 95% CI = 2.31-3.36, P<0.01). CONCLUSIONS: The APOC1 insertion allele, in combination with APOE ε4, likely serves as a potential risk factor for developing AD. |
| first_indexed | 2024-12-12T15:47:57Z |
| format | Article |
| id | doaj.art-b58fddf59519451da660a84e82ae2f49 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T15:47:57Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b58fddf59519451da660a84e82ae2f492022-12-22T00:19:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8701710.1371/journal.pone.0087017Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis.Qin ZhouFan ZhaoZe-ping LvChen-guang ZhengWei-dong ZhengLiang SunNa-na WangShenghang PangFabiana Michelsen de AndradeMian FuXiang-hua HeJuan HuiWenyYu JiangChu-yu YangXiao-hong ShiXiao-quan ZhuGuo-fang PangYi-ge YangHai-qun XieWan-dong ZhangCai-you HuZe YangBACKGROUND: Previous association studies examining the relationship between the APOC1 polymorphism and susceptibility to Alzheimer's disease (AD) have shown conflicting results, and it is not clear if an APOC1 variant acts as a genetic risk factor in AD etiology across multiple populations. METHODS: To confirm the risk association between APOC1 and AD, we designed a case-control study and also performed a meta-analysis of previously published studies. RESULTS: Seventy-nine patients with AD and one hundred fifty-six unrelated controls were included in case-control study. No association was found between the variation of APOC1 and AD in stage 1 of our study. However, our meta-analysis pooled a total of 2092 AD patients and 2685 controls. The APOC1 rs11568822 polymorphism was associated with increased AD risk in Caucasians, Asians and Caribbean Hispanics, but not in African Americans. APOE ε4 carriers harboring the APOC1 insertion allele, were more prevalent in AD patients than controls (χ(2) = 119.46, OR = 2.79, 95% CI = 2.31-3.36, P<0.01). CONCLUSIONS: The APOC1 insertion allele, in combination with APOE ε4, likely serves as a potential risk factor for developing AD.http://europepmc.org/articles/PMC3909044?pdf=render |
| spellingShingle | Qin Zhou Fan Zhao Ze-ping Lv Chen-guang Zheng Wei-dong Zheng Liang Sun Na-na Wang Shenghang Pang Fabiana Michelsen de Andrade Mian Fu Xiang-hua He Juan Hui WenyYu Jiang Chu-yu Yang Xiao-hong Shi Xiao-quan Zhu Guo-fang Pang Yi-ge Yang Hai-qun Xie Wan-dong Zhang Cai-you Hu Ze Yang Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis. PLoS ONE |
| title | Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis. |
| title_full | Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis. |
| title_fullStr | Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis. |
| title_full_unstemmed | Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis. |
| title_short | Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis. |
| title_sort | association between apoc1 polymorphism and alzheimer s disease a case control study and meta analysis |
| url | http://europepmc.org/articles/PMC3909044?pdf=render |
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