Pharmacokinetics and tissue and milk disposition of Tilmicosin in sheep after single administrations
Tilmicosin was administered to sheep intravenously and subcutaneously to determine its concentration in blood, tissue and milk and its kinetic behaviour. After a slow intravenous and subcutaneous injection, the serum concentration-time curve indicated a two compartment open model , elimination half-...
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| Format: | Article |
| Language: | English |
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University of Anbar
2012-06-01
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| Series: | مجلة جامعة الانبار للعلوم الصرفة |
| Subjects: | |
| Online Access: | https://juaps.uoanbar.edu.iq/article_15503_dcf412067b892e206a5e3dd17af88cf3.pdf |
| _version_ | 1797373358436777984 |
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| author | Arooba M.S. Ibrahim |
| author_facet | Arooba M.S. Ibrahim |
| author_sort | Arooba M.S. Ibrahim |
| collection | DOAJ |
| description | Tilmicosin was administered to sheep intravenously and subcutaneously to determine its concentration in blood, tissue and milk and its kinetic behaviour. After a slow intravenous and subcutaneous injection, the serum concentration-time curve indicated a two compartment open model , elimination half-life (t1/2β) of (4•36 ± 0•04) hours. After a subcutaneous injection the peak plasma drug concentration was (22.54 ± 0.62) mg/ml (Cmax) at 0.5h (Tmax) and the drug was rapidly absorbed and slowly eliminated (t1/2β: 5•02 ± 0•08) h. The apparent volume of distribution of tilmicosin was more than (1.89 ± 0.041). Tilmicosin residues found in liver, kidney and tissue after the 14 and 28 day of withdrawal after intravenous and subcutaneous respectively. Tilmicosin was extensively secreted into milk, Tilmicosin was detectable in milk for 5 and 28 days after a single dose intravenous and subcutaneous respectively |
| first_indexed | 2024-03-08T18:49:21Z |
| format | Article |
| id | doaj.art-b590340614794fe4874af88ce6877504 |
| institution | Directory Open Access Journal |
| issn | 1991-8941 2706-6703 |
| language | English |
| last_indexed | 2024-03-08T18:49:21Z |
| publishDate | 2012-06-01 |
| publisher | University of Anbar |
| record_format | Article |
| series | مجلة جامعة الانبار للعلوم الصرفة |
| spelling | doaj.art-b590340614794fe4874af88ce68775042023-12-28T21:55:28ZengUniversity of Anbarمجلة جامعة الانبار للعلوم الصرفة1991-89412706-67032012-06-015171210.37652/juaps.2011.1550315503Pharmacokinetics and tissue and milk disposition of Tilmicosin in sheep after single administrationsArooba M.S. Ibrahim0University of Baghdad - College of Vet. Med.Tilmicosin was administered to sheep intravenously and subcutaneously to determine its concentration in blood, tissue and milk and its kinetic behaviour. After a slow intravenous and subcutaneous injection, the serum concentration-time curve indicated a two compartment open model , elimination half-life (t1/2β) of (4•36 ± 0•04) hours. After a subcutaneous injection the peak plasma drug concentration was (22.54 ± 0.62) mg/ml (Cmax) at 0.5h (Tmax) and the drug was rapidly absorbed and slowly eliminated (t1/2β: 5•02 ± 0•08) h. The apparent volume of distribution of tilmicosin was more than (1.89 ± 0.041). Tilmicosin residues found in liver, kidney and tissue after the 14 and 28 day of withdrawal after intravenous and subcutaneous respectively. Tilmicosin was extensively secreted into milk, Tilmicosin was detectable in milk for 5 and 28 days after a single dose intravenous and subcutaneous respectivelyhttps://juaps.uoanbar.edu.iq/article_15503_dcf412067b892e206a5e3dd17af88cf3.pdfpharmacokineticstissuemilk dispositiontilmicosinsheep |
| spellingShingle | Arooba M.S. Ibrahim Pharmacokinetics and tissue and milk disposition of Tilmicosin in sheep after single administrations مجلة جامعة الانبار للعلوم الصرفة pharmacokinetics tissue milk disposition tilmicosin sheep |
| title | Pharmacokinetics and tissue and milk disposition of Tilmicosin in sheep after single administrations |
| title_full | Pharmacokinetics and tissue and milk disposition of Tilmicosin in sheep after single administrations |
| title_fullStr | Pharmacokinetics and tissue and milk disposition of Tilmicosin in sheep after single administrations |
| title_full_unstemmed | Pharmacokinetics and tissue and milk disposition of Tilmicosin in sheep after single administrations |
| title_short | Pharmacokinetics and tissue and milk disposition of Tilmicosin in sheep after single administrations |
| title_sort | pharmacokinetics and tissue and milk disposition of tilmicosin in sheep after single administrations |
| topic | pharmacokinetics tissue milk disposition tilmicosin sheep |
| url | https://juaps.uoanbar.edu.iq/article_15503_dcf412067b892e206a5e3dd17af88cf3.pdf |
| work_keys_str_mv | AT aroobamsibrahim pharmacokineticsandtissueandmilkdispositionoftilmicosininsheepaftersingleadministrations |