pH-responsive carboxylic cellulose acetate nanoparticles for controlled release of penicillin G
In this study, pH responsive carboxylic cellulose acetate nanoparticles (CCA NPs) have been evaluated as drug nanocarriers for controlled release of drug. Herein, carboxylic cellulose acetate (CCA) was initially synthesized via oxidation of cellulose using a 2,2,6,6-tetramethylpiperidin-1-yl)oxidany...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Journal of Science: Advanced Materials and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468217920300289 |
| _version_ | 1818042930846236672 |
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| author | Boon-Kui Ho Suk-Fun Chin Suh-Cem Pang |
| author_facet | Boon-Kui Ho Suk-Fun Chin Suh-Cem Pang |
| author_sort | Boon-Kui Ho |
| collection | DOAJ |
| description | In this study, pH responsive carboxylic cellulose acetate nanoparticles (CCA NPs) have been evaluated as drug nanocarriers for controlled release of drug. Herein, carboxylic cellulose acetate (CCA) was initially synthesized via oxidation of cellulose using a 2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl (TEMPO) as an oxidant and followed by the acetylation of carboxylic cellulose in the presence of iodine as a catalyst. CCA NPs were then obtained via the nanoprecipitation process and subsequent sonication. The obtained CCA NPs with a mean diameter of 96 nm were subsequently evaluated as drug delivery nanocarriers. Penicillin G as a model drug was loaded onto the CCA NPs via the adsorption process. Drug release profiles of Penicillin G from CCA NPs were evaluated in phosphate buffer solution (PBS) at different medium pH values (1.2, 7.4, and 8.6). Release kinetic models were applied to determine the release mechanism of penicillin G from loaded CCA NPs. Results showed that pH-responsive release of penicillin G from CCA NPs which was released most slowly at medium of pH 7.4. |
| first_indexed | 2024-12-10T08:54:09Z |
| format | Article |
| id | doaj.art-b5909b8cb2064795ab0ccb7e5ba17d25 |
| institution | Directory Open Access Journal |
| issn | 2468-2179 |
| language | English |
| last_indexed | 2024-12-10T08:54:09Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Science: Advanced Materials and Devices |
| spelling | doaj.art-b5909b8cb2064795ab0ccb7e5ba17d252022-12-22T01:55:30ZengElsevierJournal of Science: Advanced Materials and Devices2468-21792020-06-0152224232pH-responsive carboxylic cellulose acetate nanoparticles for controlled release of penicillin GBoon-Kui Ho0Suk-Fun Chin1Suh-Cem Pang2Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, MalaysiaCorresponding author.; Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, MalaysiaFaculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, MalaysiaIn this study, pH responsive carboxylic cellulose acetate nanoparticles (CCA NPs) have been evaluated as drug nanocarriers for controlled release of drug. Herein, carboxylic cellulose acetate (CCA) was initially synthesized via oxidation of cellulose using a 2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl (TEMPO) as an oxidant and followed by the acetylation of carboxylic cellulose in the presence of iodine as a catalyst. CCA NPs were then obtained via the nanoprecipitation process and subsequent sonication. The obtained CCA NPs with a mean diameter of 96 nm were subsequently evaluated as drug delivery nanocarriers. Penicillin G as a model drug was loaded onto the CCA NPs via the adsorption process. Drug release profiles of Penicillin G from CCA NPs were evaluated in phosphate buffer solution (PBS) at different medium pH values (1.2, 7.4, and 8.6). Release kinetic models were applied to determine the release mechanism of penicillin G from loaded CCA NPs. Results showed that pH-responsive release of penicillin G from CCA NPs which was released most slowly at medium of pH 7.4.http://www.sciencedirect.com/science/article/pii/S2468217920300289Carboxylic cellulose acetateNanoparticlespH-responsivePenicillin G |
| spellingShingle | Boon-Kui Ho Suk-Fun Chin Suh-Cem Pang pH-responsive carboxylic cellulose acetate nanoparticles for controlled release of penicillin G Journal of Science: Advanced Materials and Devices Carboxylic cellulose acetate Nanoparticles pH-responsive Penicillin G |
| title | pH-responsive carboxylic cellulose acetate nanoparticles for controlled release of penicillin G |
| title_full | pH-responsive carboxylic cellulose acetate nanoparticles for controlled release of penicillin G |
| title_fullStr | pH-responsive carboxylic cellulose acetate nanoparticles for controlled release of penicillin G |
| title_full_unstemmed | pH-responsive carboxylic cellulose acetate nanoparticles for controlled release of penicillin G |
| title_short | pH-responsive carboxylic cellulose acetate nanoparticles for controlled release of penicillin G |
| title_sort | ph responsive carboxylic cellulose acetate nanoparticles for controlled release of penicillin g |
| topic | Carboxylic cellulose acetate Nanoparticles pH-responsive Penicillin G |
| url | http://www.sciencedirect.com/science/article/pii/S2468217920300289 |
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