Secondhand smoke increases the risk of developing chronic obstructive pulmonary disease
Abstract Smoking is the most important risk factor for chronic obstructive pulmonary disease (COPD), however evidence from large-scale studies on whether secondhand smoke (SHS) increases the risk of COPD is still lacking. We conducted this large longitudinal study to investigate the association betw...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-58038-2 |
| _version_ | 1827301203427459072 |
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| author | Wen-Chi Su Huai-Lei Juan Jia-In Lee Shu-Pin Huang Szu-Chia Chen Jiun-Hung Geng |
| author_facet | Wen-Chi Su Huai-Lei Juan Jia-In Lee Shu-Pin Huang Szu-Chia Chen Jiun-Hung Geng |
| author_sort | Wen-Chi Su |
| collection | DOAJ |
| description | Abstract Smoking is the most important risk factor for chronic obstructive pulmonary disease (COPD), however evidence from large-scale studies on whether secondhand smoke (SHS) increases the risk of COPD is still lacking. We conducted this large longitudinal study to investigate the association between SHS and the development of COPD. This is a longitudinal study. Data on 6519 subjects who were never-smokers, had no history of COPD, and had complete lung function records were extracted from the Taiwan Biobank. They were divided into two groups according to SHS exposure: no exposure and exposure groups. Data were collected when participants enrolled in the study and during regular follow-up. Cox proportional hazards regression models were used to estimate the relative risk (RR) and 95% confidence interval (CI) for the association between SHS and the risk of developing COPD. At 48 months of follow-up, 260 (4%) participants in the no exposure group and 34 (7%) participants in the exposure group developed COPD. The RR of incident COPD development was significantly higher in the exposure group than that in the no exposure group after adjusting for confounders (RR = 1.49; 95% CI 1.04 to 2.14; P value = 0.031). There is a dose–response relationship between the duration of exposure to SHS and the risk of incident COPD, which demonstrates that an additional hour of exposure to SHS per week was associated with a 1.03-fold increased likelihood of developing COPD after adjusting for confounders (RR = 1.03; 95% CI 1.00 to 1.05; P value = 0.027). SHS exposure contributes to the development of COPD. This finding can help raise awareness of the harms of SHS and provide a reference for formulating anti-smoking policies. |
| first_indexed | 2024-04-24T16:18:59Z |
| format | Article |
| id | doaj.art-b590d62bbb50425084d84eaa748f83d3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T16:18:59Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b590d62bbb50425084d84eaa748f83d32024-03-31T11:18:50ZengNature PortfolioScientific Reports2045-23222024-03-011411910.1038/s41598-024-58038-2Secondhand smoke increases the risk of developing chronic obstructive pulmonary diseaseWen-Chi Su0Huai-Lei Juan1Jia-In Lee2Shu-Pin Huang3Szu-Chia Chen4Jiun-Hung Geng5Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical UniversityDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical UniversityDepartment of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical UniversityGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical UniversityFaculty of Medicine, College of Medicine, Kaohsiung Medical UniversityFaculty of Medicine, College of Medicine, Kaohsiung Medical UniversityAbstract Smoking is the most important risk factor for chronic obstructive pulmonary disease (COPD), however evidence from large-scale studies on whether secondhand smoke (SHS) increases the risk of COPD is still lacking. We conducted this large longitudinal study to investigate the association between SHS and the development of COPD. This is a longitudinal study. Data on 6519 subjects who were never-smokers, had no history of COPD, and had complete lung function records were extracted from the Taiwan Biobank. They were divided into two groups according to SHS exposure: no exposure and exposure groups. Data were collected when participants enrolled in the study and during regular follow-up. Cox proportional hazards regression models were used to estimate the relative risk (RR) and 95% confidence interval (CI) for the association between SHS and the risk of developing COPD. At 48 months of follow-up, 260 (4%) participants in the no exposure group and 34 (7%) participants in the exposure group developed COPD. The RR of incident COPD development was significantly higher in the exposure group than that in the no exposure group after adjusting for confounders (RR = 1.49; 95% CI 1.04 to 2.14; P value = 0.031). There is a dose–response relationship between the duration of exposure to SHS and the risk of incident COPD, which demonstrates that an additional hour of exposure to SHS per week was associated with a 1.03-fold increased likelihood of developing COPD after adjusting for confounders (RR = 1.03; 95% CI 1.00 to 1.05; P value = 0.027). SHS exposure contributes to the development of COPD. This finding can help raise awareness of the harms of SHS and provide a reference for formulating anti-smoking policies.https://doi.org/10.1038/s41598-024-58038-2 |
| spellingShingle | Wen-Chi Su Huai-Lei Juan Jia-In Lee Shu-Pin Huang Szu-Chia Chen Jiun-Hung Geng Secondhand smoke increases the risk of developing chronic obstructive pulmonary disease Scientific Reports |
| title | Secondhand smoke increases the risk of developing chronic obstructive pulmonary disease |
| title_full | Secondhand smoke increases the risk of developing chronic obstructive pulmonary disease |
| title_fullStr | Secondhand smoke increases the risk of developing chronic obstructive pulmonary disease |
| title_full_unstemmed | Secondhand smoke increases the risk of developing chronic obstructive pulmonary disease |
| title_short | Secondhand smoke increases the risk of developing chronic obstructive pulmonary disease |
| title_sort | secondhand smoke increases the risk of developing chronic obstructive pulmonary disease |
| url | https://doi.org/10.1038/s41598-024-58038-2 |
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