A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma

A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma

Abstract Background Triple-negative mammary carcinoma (TNBC) is an aggressive breast cancer subtype associated with dismal prognosis. The interaction between the immune system and the cancer cells plays a crucial role in tumor development and progression. However, it is still unclear how each divers...

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Bibliographic Details
Main Authors: Monique C. Tavares, Cristina D. Sampaio, Geraldine E. Lima, Victor P. Andrade, Daniel G. Gonçalves, Mariana P. Macedo, Vladmir C. Cordeiro de Lima
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Cancer
Subjects:
Triple-negative breast cancer
Immune infiltrate
PTEN
CD8
FOXP3
Survival
Online Access:https://doi.org/10.1186/s12885-021-08636-4

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