Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model
Abstract Muscle overuse and its consequent muscle damage has no cure. Therefore, the present study aimed to investigate the regulatory role of tau-AuNPs on muscle recovery of muscle overuse model. The animals (Male Swiss mice) were randomly divided into four groups: Control (Ctr; n=6); tau-AuNPs (n=...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2021-05-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000300808&tlng=en |
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| author | ANAND THIRUPATHI HELEN R. SORATO PAULO R.L. SILVA ADRIANI P. DAMIANI VANESSA M. ANDRADE PAULO C.L. SILVEIRA RENATA T. NESI MARCOS M.S. PAULA RICARDO A. PINHO |
| author_facet | ANAND THIRUPATHI HELEN R. SORATO PAULO R.L. SILVA ADRIANI P. DAMIANI VANESSA M. ANDRADE PAULO C.L. SILVEIRA RENATA T. NESI MARCOS M.S. PAULA RICARDO A. PINHO |
| author_sort | ANAND THIRUPATHI |
| collection | DOAJ |
| description | Abstract Muscle overuse and its consequent muscle damage has no cure. Therefore, the present study aimed to investigate the regulatory role of tau-AuNPs on muscle recovery of muscle overuse model. The animals (Male Swiss mice) were randomly divided into four groups: Control (Ctr; n=6); tau-AuNPs (n=6); overuse (n=6); and overuse plus tau-AuNPs (n=6). Exercise sessions were performed for 21 consecutive days, and one exercise model was applied daily in the following sequence: low intensity, moderate intensity, and high intensity. The mice were then sacrificed. The quadriceps muscles were surgically removed for subsequent biochemical analysis (oxidative stress parameters, DNA damage markers and muscle differentiation protein). The overuse group significantly increased the oxidative stress parameters and DNA damage markers, whereas tau-AuNPs significantly decreased the oxidative stress parameters in the overuse animal model. However, there were no significant differences observed between overuse group and overuse plus tau-AuNPs administrated group in relation to DNA damage markers including DNA damage frequency and index levels when compared to control and tau-AuNPs groups. Muscle differentiation protein Myf-5 was increased in the overuse plus tau-AuNPs administration group when compared to control group. In conclusion, tau-AuNPs had significant effect on reducing oxidative stress parameters and increasing myogenic regulatory protein Myf-5 in the overuse group. However, it did not have significant effect on reducing DNA damage. |
| first_indexed | 2024-12-24T01:19:50Z |
| format | Article |
| id | doaj.art-b59170980d444873bb3f9e782c88f10d |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-24T01:19:50Z |
| publishDate | 2021-05-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-b59170980d444873bb3f9e782c88f10d2022-12-21T17:22:41ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902021-05-0193210.1590/0001-3765202120191450Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse modelANAND THIRUPATHIhttps://orcid.org/0000-0002-0924-2538HELEN R. SORATOhttps://orcid.org/0000-0002-0592-7337PAULO R.L. SILVAhttps://orcid.org/0000-0001-7787-8530ADRIANI P. DAMIANIhttps://orcid.org/0000-0002-2908-7125VANESSA M. ANDRADEhttps://orcid.org/0000-0002-8474-4482PAULO C.L. SILVEIRAhttps://orcid.org/0000-0003-4908-2257RENATA T. NESIhttps://orcid.org/0000-0002-6774-0893MARCOS M.S. PAULAhttps://orcid.org/0000-0003-1383-9174RICARDO A. PINHOhttps://orcid.org/0000-0003-3116-4553Abstract Muscle overuse and its consequent muscle damage has no cure. Therefore, the present study aimed to investigate the regulatory role of tau-AuNPs on muscle recovery of muscle overuse model. The animals (Male Swiss mice) were randomly divided into four groups: Control (Ctr; n=6); tau-AuNPs (n=6); overuse (n=6); and overuse plus tau-AuNPs (n=6). Exercise sessions were performed for 21 consecutive days, and one exercise model was applied daily in the following sequence: low intensity, moderate intensity, and high intensity. The mice were then sacrificed. The quadriceps muscles were surgically removed for subsequent biochemical analysis (oxidative stress parameters, DNA damage markers and muscle differentiation protein). The overuse group significantly increased the oxidative stress parameters and DNA damage markers, whereas tau-AuNPs significantly decreased the oxidative stress parameters in the overuse animal model. However, there were no significant differences observed between overuse group and overuse plus tau-AuNPs administrated group in relation to DNA damage markers including DNA damage frequency and index levels when compared to control and tau-AuNPs groups. Muscle differentiation protein Myf-5 was increased in the overuse plus tau-AuNPs administration group when compared to control group. In conclusion, tau-AuNPs had significant effect on reducing oxidative stress parameters and increasing myogenic regulatory protein Myf-5 in the overuse group. However, it did not have significant effect on reducing DNA damage.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000300808&tlng=enMuscle overusetaurineAuNPsoxidative stress |
| spellingShingle | ANAND THIRUPATHI HELEN R. SORATO PAULO R.L. SILVA ADRIANI P. DAMIANI VANESSA M. ANDRADE PAULO C.L. SILVEIRA RENATA T. NESI MARCOS M.S. PAULA RICARDO A. PINHO Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model Anais da Academia Brasileira de Ciências Muscle overuse taurine AuNPs oxidative stress |
| title | Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model |
| title_full | Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model |
| title_fullStr | Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model |
| title_full_unstemmed | Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model |
| title_short | Effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model |
| title_sort | effect of taurine associated gold nanoparticles on oxidative stress in muscle of mice exposed to overuse model |
| topic | Muscle overuse taurine AuNPs oxidative stress |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000300808&tlng=en |
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