Macrophage Autophagy and Bacterial Infections
Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. One of the most studied is probably xenophagy, the selective capture and degradation of intracellular bacteria by lysosomes. However, the impact of autophagy goes beyond xenophagy and involves i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01483/full |
| _version_ | 1817999201039024128 |
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| author | Aïcha Bah Isabelle Vergne |
| author_facet | Aïcha Bah Isabelle Vergne |
| author_sort | Aïcha Bah |
| collection | DOAJ |
| description | Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. One of the most studied is probably xenophagy, the selective capture and degradation of intracellular bacteria by lysosomes. However, the impact of autophagy goes beyond xenophagy and involves intensive cross-talks with other host defense mechanisms. In addition, autophagy machinery can have non-canonical functions such as LC3-associated phagocytosis. In this review, we intend to summarize the current knowledge on the many functions of autophagy proteins in cell defenses with a focus on bacteria–macrophage interaction. We also present the strategies developed by pathogens to evade or to exploit this machinery in order to establish a successful infection. Finally, we discuss the opportunities and challenges of autophagy manipulation in improving therapeutics and vaccines against bacterial pathogens. |
| first_indexed | 2024-04-14T03:05:10Z |
| format | Article |
| id | doaj.art-b5921bb35ce741d0bd730d1022f845b4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T03:05:10Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b5921bb35ce741d0bd730d1022f845b42022-12-22T02:15:47ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-11-01810.3389/fimmu.2017.01483310909Macrophage Autophagy and Bacterial InfectionsAïcha Bah0Isabelle Vergne1Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS—Université de Toulouse, Toulouse, FranceInstitut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS—Université de Toulouse, Toulouse, FranceAutophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. One of the most studied is probably xenophagy, the selective capture and degradation of intracellular bacteria by lysosomes. However, the impact of autophagy goes beyond xenophagy and involves intensive cross-talks with other host defense mechanisms. In addition, autophagy machinery can have non-canonical functions such as LC3-associated phagocytosis. In this review, we intend to summarize the current knowledge on the many functions of autophagy proteins in cell defenses with a focus on bacteria–macrophage interaction. We also present the strategies developed by pathogens to evade or to exploit this machinery in order to establish a successful infection. Finally, we discuss the opportunities and challenges of autophagy manipulation in improving therapeutics and vaccines against bacterial pathogens.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01483/fullautophagymacrophagebacteriapathogenphagocytosisxenophagy |
| spellingShingle | Aïcha Bah Isabelle Vergne Macrophage Autophagy and Bacterial Infections Frontiers in Immunology autophagy macrophage bacteria pathogen phagocytosis xenophagy |
| title | Macrophage Autophagy and Bacterial Infections |
| title_full | Macrophage Autophagy and Bacterial Infections |
| title_fullStr | Macrophage Autophagy and Bacterial Infections |
| title_full_unstemmed | Macrophage Autophagy and Bacterial Infections |
| title_short | Macrophage Autophagy and Bacterial Infections |
| title_sort | macrophage autophagy and bacterial infections |
| topic | autophagy macrophage bacteria pathogen phagocytosis xenophagy |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01483/full |
| work_keys_str_mv | AT aichabah macrophageautophagyandbacterialinfections AT isabellevergne macrophageautophagyandbacterialinfections |