Combination of Cordycepin and Apatinib Synergistically Inhibits NSCLC Cells by Down-Regulating VEGF/PI3K/Akt Signaling Pathway

Combination of Cordycepin and Apatinib Synergistically Inhibits NSCLC Cells by Down-Regulating VEGF/PI3K/Akt Signaling Pathway

BackgroundThe application of apatinib is immensely limited by its acquired drug resistance. This research investigates whether cordycepin, a component from Cordyceps could synergize with apatinib to improve its anticancer effect on non-small cell lung cancer (NSCLC) cells.MethodsThe NSCLC cell lines...

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Bibliographic Details
Main Authors: Xiaozhong Liao, Lanting Tao, Wei Guo, Zhuo-Xun Wu, Haiyan Du, Jing Wang, Jue Zhang, Hanrui Chen, Zhe-Sheng Chen, Lizhu Lin, Lingling Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
cordycepin
apatinib
synergistic effect
A549
PC9
VEGF/PI3K/Akt signal pathway
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01732/full

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