Pathogenic Role and Antibiotic Resistance of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Strains Causing Severe Community-Acquired Pneumonia in Vietnamese Children
In recent years, the pathogenic role and antibiotic resistance of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) strains causing severe community-acquired pneumonia (CAP) have received increasing attention in clinical practice. The aim of this study was to determine the rate o...
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MDPI AG
2023-03-01
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| Series: | Advances in Respiratory Medicine |
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| Online Access: | https://www.mdpi.com/2543-6031/91/2/12 |
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| author | Khai Quang Tran Thuy Thi Dieu Nguyen Van Hung Pham Quan Minh Pham Hung Do Tran |
| author_facet | Khai Quang Tran Thuy Thi Dieu Nguyen Van Hung Pham Quan Minh Pham Hung Do Tran |
| author_sort | Khai Quang Tran |
| collection | DOAJ |
| description | In recent years, the pathogenic role and antibiotic resistance of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) strains causing severe community-acquired pneumonia (CAP) have received increasing attention in clinical practice. The aim of this study was to determine the rate of isolates of MRSA strains causing severe CAP in children and to assess their level of antibiotic resistance. The study design was cross-sectional. Children with severe CAP were sampled by nasopharyngeal aspiration for the culture, isolation, and identification of MRSA. Antimicrobial susceptibility testing was performed using the gradient diffusion method to determine the minimum inhibitory concentration (MIC) of antibiotics. Results: MRSA was identified as the second leading cause of severe CAP in Vietnamese children. The rate of isolates of <i>S. aureus</i> was 41/239 (17.5%), of which most were MRSA, at 32/41 (78.0%). MRSA strains were completely non-susceptible to penicillin (100%), more resistant to clindamycin and erythromycin, less sensitive to ciprofloxacin and levofloxacin, and fully susceptible to vancomycin and linezolid, with a 32-fold decreased MIC<sub>90</sub> for vancomycin (0.5 mg/L) and a 2-fold decreased MIC<sub>90</sub> for linezolid (4 mg/L). Therefore, vancomycin and linezolid may be appropriate options for severe CAP identified by MRSA. |
| first_indexed | 2024-03-11T05:16:15Z |
| format | Article |
| id | doaj.art-b593c63aa3a44d26a8c9dd13c6cc3938 |
| institution | Directory Open Access Journal |
| issn | 2543-6031 |
| language | English |
| last_indexed | 2024-03-11T05:16:15Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Advances in Respiratory Medicine |
| spelling | doaj.art-b593c63aa3a44d26a8c9dd13c6cc39382023-11-17T18:15:19ZengMDPI AGAdvances in Respiratory Medicine2543-60312023-03-0191213514510.3390/arm91020012Pathogenic Role and Antibiotic Resistance of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Strains Causing Severe Community-Acquired Pneumonia in Vietnamese ChildrenKhai Quang Tran0Thuy Thi Dieu Nguyen1Van Hung Pham2Quan Minh Pham3Hung Do Tran4Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, VietnamDepartment of Pediatrics, Hanoi Medical University, Hanoi 100000, VietnamLaboratory of Nam Khoa Biotek Company, International Research of Gene and Immunology Institute, Ho Chi Minh City 700000, VietnamDepartment of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, VietnamDepartment of Nursing and Medical Technology, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, VietnamIn recent years, the pathogenic role and antibiotic resistance of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) strains causing severe community-acquired pneumonia (CAP) have received increasing attention in clinical practice. The aim of this study was to determine the rate of isolates of MRSA strains causing severe CAP in children and to assess their level of antibiotic resistance. The study design was cross-sectional. Children with severe CAP were sampled by nasopharyngeal aspiration for the culture, isolation, and identification of MRSA. Antimicrobial susceptibility testing was performed using the gradient diffusion method to determine the minimum inhibitory concentration (MIC) of antibiotics. Results: MRSA was identified as the second leading cause of severe CAP in Vietnamese children. The rate of isolates of <i>S. aureus</i> was 41/239 (17.5%), of which most were MRSA, at 32/41 (78.0%). MRSA strains were completely non-susceptible to penicillin (100%), more resistant to clindamycin and erythromycin, less sensitive to ciprofloxacin and levofloxacin, and fully susceptible to vancomycin and linezolid, with a 32-fold decreased MIC<sub>90</sub> for vancomycin (0.5 mg/L) and a 2-fold decreased MIC<sub>90</sub> for linezolid (4 mg/L). Therefore, vancomycin and linezolid may be appropriate options for severe CAP identified by MRSA.https://www.mdpi.com/2543-6031/91/2/12methicillin-resistant <i>Staphylococcus aureus</i>antibioticresistancecommunity-acquired pneumoniachildren |
| spellingShingle | Khai Quang Tran Thuy Thi Dieu Nguyen Van Hung Pham Quan Minh Pham Hung Do Tran Pathogenic Role and Antibiotic Resistance of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Strains Causing Severe Community-Acquired Pneumonia in Vietnamese Children Advances in Respiratory Medicine methicillin-resistant <i>Staphylococcus aureus</i> antibiotic resistance community-acquired pneumonia children |
| title | Pathogenic Role and Antibiotic Resistance of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Strains Causing Severe Community-Acquired Pneumonia in Vietnamese Children |
| title_full | Pathogenic Role and Antibiotic Resistance of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Strains Causing Severe Community-Acquired Pneumonia in Vietnamese Children |
| title_fullStr | Pathogenic Role and Antibiotic Resistance of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Strains Causing Severe Community-Acquired Pneumonia in Vietnamese Children |
| title_full_unstemmed | Pathogenic Role and Antibiotic Resistance of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Strains Causing Severe Community-Acquired Pneumonia in Vietnamese Children |
| title_short | Pathogenic Role and Antibiotic Resistance of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Strains Causing Severe Community-Acquired Pneumonia in Vietnamese Children |
| title_sort | pathogenic role and antibiotic resistance of methicillin resistant i staphylococcus aureus i mrsa strains causing severe community acquired pneumonia in vietnamese children |
| topic | methicillin-resistant <i>Staphylococcus aureus</i> antibiotic resistance community-acquired pneumonia children |
| url | https://www.mdpi.com/2543-6031/91/2/12 |
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