Inflammation resolution circuits are uncoupled in acute sepsis and correlate with clinical severity

Inflammation resolution circuits are uncoupled in acute sepsis and correlate with clinical severity

Sepsis is a critical illness characterized by dysregulated inflammatory responses lacking counter-regulation. Specialized proresolving mediators are agonists for antiinflammation and for promoting resolution, and they are protective in preclinical sepsis models. Here, in human sepsis, we mapped reso...

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Bibliographic Details
Main Authors: Bakr Jundi, Do-Hyun Lee, Hyungkook Jeon, Melody G. Duvall, Julie Nijmeh, Raja-Elie E. Abdulnour, Mayra Pinilla-Vera, Rebecca M. Baron, Jongyoon Han, Joel Voldman, Bruce D. Levy
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-08-01
Series:JCI Insight
Subjects:
Inflammation
Pulmonology
Online Access:https://doi.org/10.1172/jci.insight.148866

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