Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor
Recently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal vascular resistance (RVR) responses to Ang1-7...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Research in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=2;spage=177;epage=180;aulast=Nematbakhsh |
| _version_ | 1818656432111747072 |
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| author | Mehdi Nematbakhsh Azam Mansouri |
| author_facet | Mehdi Nematbakhsh Azam Mansouri |
| author_sort | Mehdi Nematbakhsh |
| collection | DOAJ |
| description | Recently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal vascular resistance (RVR) responses to Ang1-7 (300 ng/kg/min) infusion in the absence of Ang II receptors in male and female rats were determined at controlled renal perfusion pressure. Ang1-7 infusion did not alter mean arterial pressure in male and female rats. However, A779 compared to vehicle increased RBF (18% vs 3%) and decreased RVR (13% vs 4%) responses to Ang1-7 infusion significantly (P < 0.05) in male when AngII receptors were blocked. Such observation was not occurred in female animals. Finally it was concluded that renal vascular responses to Ang1-7 administration may not be exerted by MasR in male rats, and these responses are not mediated with AngII receptors. |
| first_indexed | 2024-12-17T03:25:29Z |
| format | Article |
| id | doaj.art-b5954b2212434aef8ca84dd7d1bfa16b |
| institution | Directory Open Access Journal |
| issn | 1735-5362 1735-9414 |
| language | English |
| last_indexed | 2024-12-17T03:25:29Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Research in Pharmaceutical Sciences |
| spelling | doaj.art-b5954b2212434aef8ca84dd7d1bfa16b2022-12-21T22:05:24ZengWolters Kluwer Medknow PublicationsResearch in Pharmaceutical Sciences1735-53621735-94142018-01-0113217718010.4103/1735-5362.223803Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptorMehdi NematbakhshAzam MansouriRecently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal vascular resistance (RVR) responses to Ang1-7 (300 ng/kg/min) infusion in the absence of Ang II receptors in male and female rats were determined at controlled renal perfusion pressure. Ang1-7 infusion did not alter mean arterial pressure in male and female rats. However, A779 compared to vehicle increased RBF (18% vs 3%) and decreased RVR (13% vs 4%) responses to Ang1-7 infusion significantly (P < 0.05) in male when AngII receptors were blocked. Such observation was not occurred in female animals. Finally it was concluded that renal vascular responses to Ang1-7 administration may not be exerted by MasR in male rats, and these responses are not mediated with AngII receptors.http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=2;spage=177;epage=180;aulast=Nematbakhshangtensin1-7; angiotensin ii receptors; mas receptor; gender; rat |
| spellingShingle | Mehdi Nematbakhsh Azam Mansouri Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor Research in Pharmaceutical Sciences angtensin1-7; angiotensin ii receptors; mas receptor; gender; rat |
| title | Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor |
| title_full | Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor |
| title_fullStr | Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor |
| title_full_unstemmed | Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor |
| title_short | Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor |
| title_sort | renal vascular response to angiotensin 1 7 in rats the role of mas receptor |
| topic | angtensin1-7; angiotensin ii receptors; mas receptor; gender; rat |
| url | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=2;spage=177;epage=180;aulast=Nematbakhsh |
| work_keys_str_mv | AT mehdinematbakhsh renalvascularresponsetoangiotensin17inratstheroleofmasreceptor AT azammansouri renalvascularresponsetoangiotensin17inratstheroleofmasreceptor |