Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature
Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report cases from our institute with colorectal cancer who experienced severe toxicities to standard dose 5-FU based chemotherapy. <i>DPYD</i> gene sequen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Clinics and Practice |
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| Online Access: | https://www.mdpi.com/2039-7283/11/3/62 |
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| author | Nedal Bukhari Abdulraheem Alshangiti Emad Tashkandi Mohammed Algarni Humaid O. Al-Shamsi Hamoud Al-Khallaf |
| author_facet | Nedal Bukhari Abdulraheem Alshangiti Emad Tashkandi Mohammed Algarni Humaid O. Al-Shamsi Hamoud Al-Khallaf |
| author_sort | Nedal Bukhari |
| collection | DOAJ |
| description | Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report cases from our institute with colorectal cancer who experienced severe toxicities to standard dose 5-FU based chemotherapy. <i>DPYD</i> gene sequencing revealed rare different polymorphisms that prompted dose adjustments of administered 5-FU and capecitabine. To our knowledge, this is the first case series looking at <i>DPYD</i> polymorphisms in the Saudi Arabian population. |
| first_indexed | 2024-03-10T07:47:41Z |
| format | Article |
| id | doaj.art-b59602066cf7468bbbe7ac0368d66f7c |
| institution | Directory Open Access Journal |
| issn | 2039-7283 |
| language | English |
| last_indexed | 2024-03-10T07:47:41Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj.art-b59602066cf7468bbbe7ac0368d66f7c2023-11-22T12:32:14ZengMDPI AGClinics and Practice2039-72832021-07-0111346747110.3390/clinpract11030062Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the LiteratureNedal Bukhari0Abdulraheem Alshangiti1Emad Tashkandi2Mohammed Algarni3Humaid O. Al-Shamsi4Hamoud Al-Khallaf5Department of Medical Oncology, King Fahad Specialist Hospital, Dammam 31444, Saudi ArabiaDepartment of Medical Oncology, King Fahad Specialist Hospital, Dammam 31444, Saudi ArabiaOncology Centre, King Abdullah Medical City, Makkah 24246, Saudi ArabiaOncology Department, King Abdulaziz Medical City, Riyadh 11426, Saudi ArabiaDepartment of Oncology, Burjeel Cancer Institute, Burjeel Medical City, Abu Dhabi 999041, United Arab EmiratesDepartment of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Dammam 31444, Saudi ArabiaDihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report cases from our institute with colorectal cancer who experienced severe toxicities to standard dose 5-FU based chemotherapy. <i>DPYD</i> gene sequencing revealed rare different polymorphisms that prompted dose adjustments of administered 5-FU and capecitabine. To our knowledge, this is the first case series looking at <i>DPYD</i> polymorphisms in the Saudi Arabian population.https://www.mdpi.com/2039-7283/11/3/62dihydropyrimidine dehydrogenase5-FluorouuracilchemotherapyDPYDpolymorphism |
| spellingShingle | Nedal Bukhari Abdulraheem Alshangiti Emad Tashkandi Mohammed Algarni Humaid O. Al-Shamsi Hamoud Al-Khallaf Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature Clinics and Practice dihydropyrimidine dehydrogenase 5-Fluorouuracil chemotherapy DPYD polymorphism |
| title | Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature |
| title_full | Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature |
| title_fullStr | Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature |
| title_full_unstemmed | Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature |
| title_short | Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature |
| title_sort | fluoropyrimidine induced severe toxicities associated with rare dpyd polymorphisms case series from saudi arabia and a review of the literature |
| topic | dihydropyrimidine dehydrogenase 5-Fluorouuracil chemotherapy DPYD polymorphism |
| url | https://www.mdpi.com/2039-7283/11/3/62 |
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