Biological and computational studies provide insights into Caesalphinia digyna Rottler stems
Caesalpinia digyna (Rottl.) (Family: Fabaceae) is an essential medicinal plant for it's conventional uses against a kind of human disorders. This research aims to investigate the antidiarrheal, antibacterial and antifungal properties of the methanol extract of the stems extracts of the C. digyn...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Biochemistry and Biophysics Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580821000881 |
| _version_ | 1819098658081079296 |
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| author | Nazim Uddin Emon Md Munsur Alam Md Solaman Uddin Sawon Ezazul Hoque Rana Marufa Afroj Mohammad Mehedi Hasan Tanvir |
| author_facet | Nazim Uddin Emon Md Munsur Alam Md Solaman Uddin Sawon Ezazul Hoque Rana Marufa Afroj Mohammad Mehedi Hasan Tanvir |
| author_sort | Nazim Uddin Emon |
| collection | DOAJ |
| description | Caesalpinia digyna (Rottl.) (Family: Fabaceae) is an essential medicinal plant for it's conventional uses against a kind of human disorders. This research aims to investigate the antidiarrheal, antibacterial and antifungal properties of the methanol extract of the stems extracts of the C. digyna (MECD). The in vivo antidiarrheal activity of the stem extracts were evaluated by using castor oil-induced diarrhea, castor oil-induced enteropooling and charcoal induced intestinal transit in mice model. Besides, in vitro antimicrobial potentiality of MECD was investigated by the disc diffusion method. In silico activity of the isolated compounds were performed by Schrödinger-Maestro (Version 11.1) software. In addition, The ADME/T analysis and PASS prediction were implemented by using pass online tools. In the antidiarrheal investigation, the MECD exhibited a notable inhibition rate in all test approaches which were statistically significant (p < 0.05, p < 0.1, p < 0.01). MECD 400 mg/kg showed the maximum antidiarrheal potency in all the test methods. In vitro antimicrobial analysis unveiled that, MECD revealed higher potentiality against almost all pathogens and indicates dose-dependent activity against almost all the bacteria and fungi. In the case of in silico evaluation of anti-diarrheal, anti-bacterial and anti-fungal activity, all three isolated compounds met the pre-conditions of Lipinski's five rules for drug discovery. Pass predicted study also employed for all compounds. However, The chemical constituents of the C. digyna can be a potent source of anti-diarrheal, anti-bacterial and anti-fungal medicine and further modification and simulation studies are required to establish the effectiveness of bioactive compounds. |
| first_indexed | 2024-12-22T00:34:29Z |
| format | Article |
| id | doaj.art-b596ea851725487787f6ef6e2df07f56 |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-12-22T00:34:29Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-b596ea851725487787f6ef6e2df07f562022-12-21T18:44:51ZengElsevierBiochemistry and Biophysics Reports2405-58082021-07-0126100994Biological and computational studies provide insights into Caesalphinia digyna Rottler stemsNazim Uddin Emon0Md Munsur Alam1Md Solaman Uddin Sawon2Ezazul Hoque Rana3Marufa Afroj4Mohammad Mehedi Hasan Tanvir5Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong, 4318, Bangladesh; Department of Public Health, School of Science and Technology, Bangladesh Open University, Gazipur, 1705, Dhaka, Bangladesh; Corresponding author. Department of Public Health, School of Science and Technology, Bangladesh Open University, Gazipur, 1705, Dhaka, Bangladesh.Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong, 4318, BangladeshDepartment of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong, 4318, BangladeshDepartment of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong, 4318, BangladeshDepartment of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong, 4318, BangladeshDepartment of Pharmacy, University of Development Alternative, Dhaka, 1209, BangladeshCaesalpinia digyna (Rottl.) (Family: Fabaceae) is an essential medicinal plant for it's conventional uses against a kind of human disorders. This research aims to investigate the antidiarrheal, antibacterial and antifungal properties of the methanol extract of the stems extracts of the C. digyna (MECD). The in vivo antidiarrheal activity of the stem extracts were evaluated by using castor oil-induced diarrhea, castor oil-induced enteropooling and charcoal induced intestinal transit in mice model. Besides, in vitro antimicrobial potentiality of MECD was investigated by the disc diffusion method. In silico activity of the isolated compounds were performed by Schrödinger-Maestro (Version 11.1) software. In addition, The ADME/T analysis and PASS prediction were implemented by using pass online tools. In the antidiarrheal investigation, the MECD exhibited a notable inhibition rate in all test approaches which were statistically significant (p < 0.05, p < 0.1, p < 0.01). MECD 400 mg/kg showed the maximum antidiarrheal potency in all the test methods. In vitro antimicrobial analysis unveiled that, MECD revealed higher potentiality against almost all pathogens and indicates dose-dependent activity against almost all the bacteria and fungi. In the case of in silico evaluation of anti-diarrheal, anti-bacterial and anti-fungal activity, all three isolated compounds met the pre-conditions of Lipinski's five rules for drug discovery. Pass predicted study also employed for all compounds. However, The chemical constituents of the C. digyna can be a potent source of anti-diarrheal, anti-bacterial and anti-fungal medicine and further modification and simulation studies are required to establish the effectiveness of bioactive compounds.http://www.sciencedirect.com/science/article/pii/S2405580821000881Caesalpinia digynaAntidiarrheaAntibacterialAntifungalMolecular docking |
| spellingShingle | Nazim Uddin Emon Md Munsur Alam Md Solaman Uddin Sawon Ezazul Hoque Rana Marufa Afroj Mohammad Mehedi Hasan Tanvir Biological and computational studies provide insights into Caesalphinia digyna Rottler stems Biochemistry and Biophysics Reports Caesalpinia digyna Antidiarrhea Antibacterial Antifungal Molecular docking |
| title | Biological and computational studies provide insights into Caesalphinia digyna Rottler stems |
| title_full | Biological and computational studies provide insights into Caesalphinia digyna Rottler stems |
| title_fullStr | Biological and computational studies provide insights into Caesalphinia digyna Rottler stems |
| title_full_unstemmed | Biological and computational studies provide insights into Caesalphinia digyna Rottler stems |
| title_short | Biological and computational studies provide insights into Caesalphinia digyna Rottler stems |
| title_sort | biological and computational studies provide insights into caesalphinia digyna rottler stems |
| topic | Caesalpinia digyna Antidiarrhea Antibacterial Antifungal Molecular docking |
| url | http://www.sciencedirect.com/science/article/pii/S2405580821000881 |
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