Viral infections associated with Kawasaki disease
Kawasaki disease (KD) is a disease of unknown cause. To investigate the infectious etiology of Kawasaki disease, we initiated a prospective case-control study to investigate possible links between common viral infections and Kawasaki disease. Methods: We enrolled 226 children with KD and 226 age- an...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-03-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664614000035 |
| _version_ | 1818527017257140224 |
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| author | Luan-Yin Chang Chun-Yi Lu Pei-Lan Shao Ping-Ing Lee Ming-Tai Lin Tsui-Yien Fan Ai-Ling Cheng Wan-Ling Lee Jen-Jan Hu Shu-Jen Yeh Chien-Chih Chang Bor-Luen Chiang Mei-Hwan Wu Li-Min Huang |
| author_facet | Luan-Yin Chang Chun-Yi Lu Pei-Lan Shao Ping-Ing Lee Ming-Tai Lin Tsui-Yien Fan Ai-Ling Cheng Wan-Ling Lee Jen-Jan Hu Shu-Jen Yeh Chien-Chih Chang Bor-Luen Chiang Mei-Hwan Wu Li-Min Huang |
| author_sort | Luan-Yin Chang |
| collection | DOAJ |
| description | Kawasaki disease (KD) is a disease of unknown cause. To investigate the infectious etiology of Kawasaki disease, we initiated a prospective case-control study to investigate possible links between common viral infections and Kawasaki disease.
Methods: We enrolled 226 children with KD and 226 age- and sex-matched healthy children from February 2004 to March 2010. Throat and nasopharyngeal swabs were taken for both viral isolation and polymerase chain reaction (PCR) for various viruses.
Results: The mean age of the 226 KD cases was 2.07 years, and the male to female ratio was 1.43 (133 boys to 93 girls). Their mean fever duration was 7.5 days with a mean peak temperature of 39.7°C. In addition to the typical symptoms of fever, neck lymphadenopathy, lip fissure and/or strawberry tongue, skin rash, nonpurulent bulbar conjunctivitis, palm/sole erythema, and induration followed by periungual desquamation, these KD cases also exhibited cough (69%), rhinorrhea (58%), and diarrhea (45%). Cases of KD had a significantly higher positive rate of viral isolation in comparison with the control group (7.5% vs. 2.2%, p = 0.02). Compared with the control group, cases of KD were more likely to have overall positive rates of viral PCR (50.4% vs. 16.4%, p < 0.001) and for various viruses including enterovirus (16.8% vs. 4.4%, p < 0.001), adenovirus (8.0% vs. 1.8%, p = 0.007), human rhinovirus (26.5% vs. 9.7%, p < 0.001), and coronavirus (7.1% vs. 0.9%, p = 0.003).
Conclusion: We found that some common respiratory viruses, such as adenoviruses, enteroviruses, rhinoviruses, and coronaviruses, were associated with KD cases. |
| first_indexed | 2024-12-11T06:30:41Z |
| format | Article |
| id | doaj.art-b598c81191524715ae3a2dada03d85a4 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-11T06:30:41Z |
| publishDate | 2014-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-b598c81191524715ae3a2dada03d85a42022-12-22T01:17:31ZengElsevierJournal of the Formosan Medical Association0929-66462014-03-01113314815410.1016/j.jfma.2013.12.008Viral infections associated with Kawasaki diseaseLuan-Yin Chang0Chun-Yi Lu1Pei-Lan Shao2Ping-Ing Lee3Ming-Tai Lin4Tsui-Yien Fan5Ai-Ling Cheng6Wan-Ling Lee7Jen-Jan Hu8Shu-Jen Yeh9Chien-Chih Chang10Bor-Luen Chiang11Mei-Hwan Wu12Li-Min Huang13Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, Taiwan Adventist Hospital, Taipei, TaiwanDepartment of Pediatrics, Far Eastern Memorial Hospital, New Taipei City, TaiwanDepartment of Pediatrics, Min-Sheng General Hospital, Tao-Yuan, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanKawasaki disease (KD) is a disease of unknown cause. To investigate the infectious etiology of Kawasaki disease, we initiated a prospective case-control study to investigate possible links between common viral infections and Kawasaki disease. Methods: We enrolled 226 children with KD and 226 age- and sex-matched healthy children from February 2004 to March 2010. Throat and nasopharyngeal swabs were taken for both viral isolation and polymerase chain reaction (PCR) for various viruses. Results: The mean age of the 226 KD cases was 2.07 years, and the male to female ratio was 1.43 (133 boys to 93 girls). Their mean fever duration was 7.5 days with a mean peak temperature of 39.7°C. In addition to the typical symptoms of fever, neck lymphadenopathy, lip fissure and/or strawberry tongue, skin rash, nonpurulent bulbar conjunctivitis, palm/sole erythema, and induration followed by periungual desquamation, these KD cases also exhibited cough (69%), rhinorrhea (58%), and diarrhea (45%). Cases of KD had a significantly higher positive rate of viral isolation in comparison with the control group (7.5% vs. 2.2%, p = 0.02). Compared with the control group, cases of KD were more likely to have overall positive rates of viral PCR (50.4% vs. 16.4%, p < 0.001) and for various viruses including enterovirus (16.8% vs. 4.4%, p < 0.001), adenovirus (8.0% vs. 1.8%, p = 0.007), human rhinovirus (26.5% vs. 9.7%, p < 0.001), and coronavirus (7.1% vs. 0.9%, p = 0.003). Conclusion: We found that some common respiratory viruses, such as adenoviruses, enteroviruses, rhinoviruses, and coronaviruses, were associated with KD cases.http://www.sciencedirect.com/science/article/pii/S0929664614000035Kawasaki diseasevirus |
| spellingShingle | Luan-Yin Chang Chun-Yi Lu Pei-Lan Shao Ping-Ing Lee Ming-Tai Lin Tsui-Yien Fan Ai-Ling Cheng Wan-Ling Lee Jen-Jan Hu Shu-Jen Yeh Chien-Chih Chang Bor-Luen Chiang Mei-Hwan Wu Li-Min Huang Viral infections associated with Kawasaki disease Journal of the Formosan Medical Association Kawasaki disease virus |
| title | Viral infections associated with Kawasaki disease |
| title_full | Viral infections associated with Kawasaki disease |
| title_fullStr | Viral infections associated with Kawasaki disease |
| title_full_unstemmed | Viral infections associated with Kawasaki disease |
| title_short | Viral infections associated with Kawasaki disease |
| title_sort | viral infections associated with kawasaki disease |
| topic | Kawasaki disease virus |
| url | http://www.sciencedirect.com/science/article/pii/S0929664614000035 |
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