fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behaviour in adolescents
High-risk behaviour in adolescents is associated with injury, mental health problems, and poor outcomes in later life. Improved understanding of the neurobiology of high-risk behaviour and impulsivity shows promise for informing clinical treatment and prevention as well as policy to better address h...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00124/full |
| _version_ | 1818011978540515328 |
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| author | Matthew R G Brown James R A Benoit Michal eJuhas Ericson eDametto Tiffanie T Tse Marnie eMacKay Bhaskar eSen Alan eCarroll Oleksandr eHodlevskyy Peter H Silverstone Florin eDolcos Serdar M Dursun Andrew James Greenshaw |
| author_facet | Matthew R G Brown James R A Benoit Michal eJuhas Ericson eDametto Tiffanie T Tse Marnie eMacKay Bhaskar eSen Alan eCarroll Oleksandr eHodlevskyy Peter H Silverstone Florin eDolcos Serdar M Dursun Andrew James Greenshaw |
| author_sort | Matthew R G Brown |
| collection | DOAJ |
| description | High-risk behaviour in adolescents is associated with injury, mental health problems, and poor outcomes in later life. Improved understanding of the neurobiology of high-risk behaviour and impulsivity shows promise for informing clinical treatment and prevention as well as policy to better address high-risk behaviour. We recruited 21 adolescents (age 14-17) with a wide range of high-risk behaviour tendencies, including medically high-risk participants recruited from psychiatric clinics. Risk tendencies were assessed using the Adolescent Risk Behaviour Screen (ARBS). ARBS risk scores correlated highly (0.78) with impulsivity scores from the Barratt Impulsivity scale (BIS). Participants underwent 4.7 Tesla functional magnetic resonance imaging (fMRI) while performing an emotional Go/NoGo task. This task presented an aversive or neutral distractor image simultaneously with each Go or NoGo stimulus. Risk behaviour and impulsivity tendencies exhibited similar but not identical associations with fMRI activation patterns in prefrontal brain regions. We interpret these results as reflecting differences in response inhibition, emotional stimulus processing, and emotion regulation in relation to participant risk behaviour tendencies and impulsivity levels. The results are consistent with high impulsivity playing an important role in determining high risk tendencies in this sample containing clinically high-risk adolescents. |
| first_indexed | 2024-04-14T06:14:19Z |
| format | Article |
| id | doaj.art-b599f371a0944a8e8b0194968223e256 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-04-14T06:14:19Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-b599f371a0944a8e8b0194968223e2562022-12-22T02:08:15ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372015-09-01910.3389/fnsys.2015.00124128111fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behaviour in adolescentsMatthew R G Brown0James R A Benoit1Michal eJuhas2Ericson eDametto3Tiffanie T Tse4Marnie eMacKay5Bhaskar eSen6Alan eCarroll7Oleksandr eHodlevskyy8Peter H Silverstone9Florin eDolcos10Serdar M Dursun11Andrew James Greenshaw12University of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of AlbertaUniversity of Illinois Urbana-ChampaignUniversity of AlbertaUniversity of AlbertaHigh-risk behaviour in adolescents is associated with injury, mental health problems, and poor outcomes in later life. Improved understanding of the neurobiology of high-risk behaviour and impulsivity shows promise for informing clinical treatment and prevention as well as policy to better address high-risk behaviour. We recruited 21 adolescents (age 14-17) with a wide range of high-risk behaviour tendencies, including medically high-risk participants recruited from psychiatric clinics. Risk tendencies were assessed using the Adolescent Risk Behaviour Screen (ARBS). ARBS risk scores correlated highly (0.78) with impulsivity scores from the Barratt Impulsivity scale (BIS). Participants underwent 4.7 Tesla functional magnetic resonance imaging (fMRI) while performing an emotional Go/NoGo task. This task presented an aversive or neutral distractor image simultaneously with each Go or NoGo stimulus. Risk behaviour and impulsivity tendencies exhibited similar but not identical associations with fMRI activation patterns in prefrontal brain regions. We interpret these results as reflecting differences in response inhibition, emotional stimulus processing, and emotion regulation in relation to participant risk behaviour tendencies and impulsivity levels. The results are consistent with high impulsivity playing an important role in determining high risk tendencies in this sample containing clinically high-risk adolescents.http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00124/fullAdolescentimpulsivityresponse inhibitionemotional Go/NoGo taskARBsHigh-risk behaviour |
| spellingShingle | Matthew R G Brown James R A Benoit Michal eJuhas Ericson eDametto Tiffanie T Tse Marnie eMacKay Bhaskar eSen Alan eCarroll Oleksandr eHodlevskyy Peter H Silverstone Florin eDolcos Serdar M Dursun Andrew James Greenshaw fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behaviour in adolescents Frontiers in Systems Neuroscience Adolescent impulsivity response inhibition emotional Go/NoGo task ARBs High-risk behaviour |
| title | fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behaviour in adolescents |
| title_full | fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behaviour in adolescents |
| title_fullStr | fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behaviour in adolescents |
| title_full_unstemmed | fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behaviour in adolescents |
| title_short | fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behaviour in adolescents |
| title_sort | fmri investigation of response inhibition emotion impulsivity and clinical high risk behaviour in adolescents |
| topic | Adolescent impulsivity response inhibition emotional Go/NoGo task ARBs High-risk behaviour |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00124/full |
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