Research progress on the role of thrombospondin 2 in malignant tumors
Thrombospondin 2 (THBS2) is a matrix cell calcium-binding glycoprotein that interacts with a variety of growth factors, receptors, matrix molecules or proteases on the extracellular matrix and cell surface. THBS2 can be activated by N6-methyladenosyl RNA methylase, and mediates tumor proliferation,...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2023-12-01
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| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-12-1881.pdf |
| _version_ | 1827391332434313216 |
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| author | MA Jiajunyan, RUI Tiannan, ZHANG Yongsheng |
| author_facet | MA Jiajunyan, RUI Tiannan, ZHANG Yongsheng |
| author_sort | MA Jiajunyan, RUI Tiannan, ZHANG Yongsheng |
| collection | DOAJ |
| description | Thrombospondin 2 (THBS2) is a matrix cell calcium-binding glycoprotein that interacts with a variety of growth factors, receptors, matrix molecules or proteases on the extracellular matrix and cell surface. THBS2 can be activated by N6-methyladenosyl RNA methylase, and mediates tumor proliferation, migration and invasion by remodeling the tumor microenvironment and participating in multiple cell signaling pathways. THBS2 could be used as a diagnostic and prognostic indicator for a variety of tumors, and is expected to become a new target for malignant tumor treatment. |
| first_indexed | 2024-03-08T17:09:07Z |
| format | Article |
| id | doaj.art-b59bb725c33d4375bc0c6c95c99eb061 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T17:09:07Z |
| publishDate | 2023-12-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-b59bb725c33d4375bc0c6c95c99eb0612024-01-04T01:10:35ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252023-12-0143121881188510.16352/j.issn.1001-6325.2023.12.1881Research progress on the role of thrombospondin 2 in malignant tumorsMA Jiajunyan, RUI Tiannan, ZHANG Yongsheng01. Department of Pathology, the Second Affiliated Hospital of Soochow University, Suzhou 215004;;2. Department of Clinical Medicine, Suzhou Medical College, Soochow University, Suzhou 215123, ChinaThrombospondin 2 (THBS2) is a matrix cell calcium-binding glycoprotein that interacts with a variety of growth factors, receptors, matrix molecules or proteases on the extracellular matrix and cell surface. THBS2 can be activated by N6-methyladenosyl RNA methylase, and mediates tumor proliferation, migration and invasion by remodeling the tumor microenvironment and participating in multiple cell signaling pathways. THBS2 could be used as a diagnostic and prognostic indicator for a variety of tumors, and is expected to become a new target for malignant tumor treatment.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-12-1881.pdfthrombospondin|thrombospondin 2|carcinoma |
| spellingShingle | MA Jiajunyan, RUI Tiannan, ZHANG Yongsheng Research progress on the role of thrombospondin 2 in malignant tumors Jichu yixue yu linchuang thrombospondin|thrombospondin 2|carcinoma |
| title | Research progress on the role of thrombospondin 2 in malignant tumors |
| title_full | Research progress on the role of thrombospondin 2 in malignant tumors |
| title_fullStr | Research progress on the role of thrombospondin 2 in malignant tumors |
| title_full_unstemmed | Research progress on the role of thrombospondin 2 in malignant tumors |
| title_short | Research progress on the role of thrombospondin 2 in malignant tumors |
| title_sort | research progress on the role of thrombospondin 2 in malignant tumors |
| topic | thrombospondin|thrombospondin 2|carcinoma |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-12-1881.pdf |
| work_keys_str_mv | AT majiajunyanruitiannanzhangyongsheng researchprogressontheroleofthrombospondin2inmalignanttumors |