Design of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies

Design of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies

ABSTRACTUpon reformatting of an antibody to single-chain variable fragment format, a region in the former variable/constant domain interface of the heavy chain becomes accessible for preexisting (PE) anti-drug antibody (ADA) binding. The region exposed because of this reformatting contains a previou...

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Bibliographic Details
Main Authors: Maria U. Johansson, Christopher Weinert, Dietrich Alexander Reichardt, Dana Mahler, Dania Diem, Christian Hess, Diana Feusi, Simon Carnal, Julia Tietz, Noreen Giezendanner, Fabio Mario Spiga, David Urech, Stefan Warmuth
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Anti-drug antibodies
antibody
antibody fragment
biotherapeutics
immunogenicity
multispecific
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2215887

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