Basis of Gene Therapy
By present time safety problems of gene therapy are widely discussed among scientists of all world. In this review results of clinical researches are summarized; explanations concerning side effects of vectors integration are given; factors that can cause genotoxicity are discussed. Approaches which...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2010-06-01
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| Series: | Медицинский вестник Юга России |
| Subjects: | |
| Online Access: | https://www.medicalherald.ru/jour/article/view/1252 |
| _version_ | 1811179413909274624 |
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| author | S. E. Ipatov S. A. Roumiantsev |
| author_facet | S. E. Ipatov S. A. Roumiantsev |
| author_sort | S. E. Ipatov |
| collection | DOAJ |
| description | By present time safety problems of gene therapy are widely discussed among scientists of all world. In this review results of clinical researches are summarized; explanations concerning side effects of vectors integration are given; factors that can cause genotoxicity are discussed. Approaches which can save or increase clinical efficacy of gene therapy with use as targets hematopoietic stem cells, thus significantly reduced risk of leukemia development and other side effects related to vectors including in genome, are presented. |
| first_indexed | 2024-04-11T06:35:13Z |
| format | Article |
| id | doaj.art-b59dca8003664ef78003259ded0cbf7b |
| institution | Directory Open Access Journal |
| issn | 2219-8075 2618-7876 |
| language | English |
| last_indexed | 2024-04-11T06:35:13Z |
| publishDate | 2010-06-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Медицинский вестник Юга России |
| spelling | doaj.art-b59dca8003664ef78003259ded0cbf7b2022-12-22T04:39:52ZengState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationМедицинский вестник Юга России2219-80752618-78762010-06-010249739Basis of Gene TherapyS. E. Ipatov0S. A. Roumiantsev1Federal Research Center of Pediatric Hematology, Oncology and ImmunologyFederal Research Center of Pediatric Hematology, Oncology and ImmunologyBy present time safety problems of gene therapy are widely discussed among scientists of all world. In this review results of clinical researches are summarized; explanations concerning side effects of vectors integration are given; factors that can cause genotoxicity are discussed. Approaches which can save or increase clinical efficacy of gene therapy with use as targets hematopoietic stem cells, thus significantly reduced risk of leukemia development and other side effects related to vectors including in genome, are presented.https://www.medicalherald.ru/jour/article/view/1252gene therapygenetic vectors |
| spellingShingle | S. E. Ipatov S. A. Roumiantsev Basis of Gene Therapy Медицинский вестник Юга России gene therapy genetic vectors |
| title | Basis of Gene Therapy |
| title_full | Basis of Gene Therapy |
| title_fullStr | Basis of Gene Therapy |
| title_full_unstemmed | Basis of Gene Therapy |
| title_short | Basis of Gene Therapy |
| title_sort | basis of gene therapy |
| topic | gene therapy genetic vectors |
| url | https://www.medicalherald.ru/jour/article/view/1252 |
| work_keys_str_mv | AT seipatov basisofgenetherapy AT saroumiantsev basisofgenetherapy |