Is insulin topical gel better than simvastatin topical gel in full thickness wound?
Due to issues of limited substances and expensive cost of wound treatment, topical insulin and simvastatin are being developed due to benefits including easy to find and applicable in every health center. Topical insulin can be used in treating diabetic patient’s wound. Simvastatin contributed in wo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2019-03-01
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| Series: | Dermatology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/index.php/dr/article/view/8051 |
| _version_ | 1818542870800367616 |
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| author | Timotius Hansen Arista Agus Santoso Budi Mirnasari Amirsyah Nanda Febry Setyawati |
| author_facet | Timotius Hansen Arista Agus Santoso Budi Mirnasari Amirsyah Nanda Febry Setyawati |
| author_sort | Timotius Hansen Arista |
| collection | DOAJ |
| description | Due to issues of limited substances and expensive cost of wound treatment, topical insulin and simvastatin are being developed due to benefits including easy to find and applicable in every health center. Topical insulin can be used in treating diabetic patient’s wound. Simvastatin contributed in wound healing process by increasing angiogenesis and lymphangiogenesis. This experimental study is using randomized post test only control design in male Wistar mice, divided in 5 treatment groups with 9 mice each : carboxymethylcellulose sodium gel, short acting insulin topical gel, long acting insulin topical gel, simvastatin topical 2% gel, and simvastatin 3% topical gel. A full thickness wound was made randomly and observed in 5 days, followed with wound biopsy and analyzing using histopathological specimen measuring the epithelial thickness, fibroblast proliferation and collagen density from each group. Long acting insulin topical gel has the highest average rate of epithelial proliferation and fibroblast proliferation. In simvastatin 3% topical gel has the highest level of collagen density level among other groups. This study showed long acting insulin topical gel significantly has better outcome than other groups. |
| first_indexed | 2024-12-11T22:27:50Z |
| format | Article |
| id | doaj.art-b5a09ed9785346d9bb5f5aa3bda4d407 |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-12-11T22:27:50Z |
| publishDate | 2019-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-b5a09ed9785346d9bb5f5aa3bda4d4072022-12-22T00:48:13ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062019-03-01111s10.4081/dr.2019.8051Is insulin topical gel better than simvastatin topical gel in full thickness wound?Timotius Hansen Arista0Agus Santoso Budi1Mirnasari Amirsyah2Nanda Febry Setyawati3Department of Plastic Reconstructive and Aeshetic Surgery, Faculty Medicine Airlangga University, Dr. Soetomo General Hospital, Surabaya, East JavaDepartment of Plastic Reconstructive and Aeshetic Surgery, Faculty Medicine Airlangga University, Dr. Soetomo General Hospital, Surabaya, East JavaDepartment of General Surgery, Faculty Medicine Syiah Kuala, Dr. Zainoel Abidin General Hospital, Banda Aceh, AcehDepartment of General Surgery, dr. Soedono General Hospital, Madiun, East JavaDue to issues of limited substances and expensive cost of wound treatment, topical insulin and simvastatin are being developed due to benefits including easy to find and applicable in every health center. Topical insulin can be used in treating diabetic patient’s wound. Simvastatin contributed in wound healing process by increasing angiogenesis and lymphangiogenesis. This experimental study is using randomized post test only control design in male Wistar mice, divided in 5 treatment groups with 9 mice each : carboxymethylcellulose sodium gel, short acting insulin topical gel, long acting insulin topical gel, simvastatin topical 2% gel, and simvastatin 3% topical gel. A full thickness wound was made randomly and observed in 5 days, followed with wound biopsy and analyzing using histopathological specimen measuring the epithelial thickness, fibroblast proliferation and collagen density from each group. Long acting insulin topical gel has the highest average rate of epithelial proliferation and fibroblast proliferation. In simvastatin 3% topical gel has the highest level of collagen density level among other groups. This study showed long acting insulin topical gel significantly has better outcome than other groups.https://www.pagepress.org/journals/index.php/dr/article/view/8051Wound healingSimvastatinInsulinTopical |
| spellingShingle | Timotius Hansen Arista Agus Santoso Budi Mirnasari Amirsyah Nanda Febry Setyawati Is insulin topical gel better than simvastatin topical gel in full thickness wound? Dermatology Reports Wound healing Simvastatin Insulin Topical |
| title | Is insulin topical gel better than simvastatin topical gel in full thickness wound? |
| title_full | Is insulin topical gel better than simvastatin topical gel in full thickness wound? |
| title_fullStr | Is insulin topical gel better than simvastatin topical gel in full thickness wound? |
| title_full_unstemmed | Is insulin topical gel better than simvastatin topical gel in full thickness wound? |
| title_short | Is insulin topical gel better than simvastatin topical gel in full thickness wound? |
| title_sort | is insulin topical gel better than simvastatin topical gel in full thickness wound |
| topic | Wound healing Simvastatin Insulin Topical |
| url | https://www.pagepress.org/journals/index.php/dr/article/view/8051 |
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