A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma
IntroductionChildhood trauma is known to have dramatic effects on the risks for developing psychiatric disorders and increased suicidality. We conducted a meta-analysis of whole brain voxel-based morphometry (VBM) correlates of childhood trauma in adolescents exposed to childhood maltreatment (N = 3...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.1022791/full |
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| author | Olga Tymofiyeva Rebecca Hu Rebecca Hu Roma Kidambi Ca Nguyen Jeffrey E. Max Jeffrey E. Max Tony T. Yang Tony T. Yang |
| author_facet | Olga Tymofiyeva Rebecca Hu Rebecca Hu Roma Kidambi Ca Nguyen Jeffrey E. Max Jeffrey E. Max Tony T. Yang Tony T. Yang |
| author_sort | Olga Tymofiyeva |
| collection | DOAJ |
| description | IntroductionChildhood trauma is known to have dramatic effects on the risks for developing psychiatric disorders and increased suicidality. We conducted a meta-analysis of whole brain voxel-based morphometry (VBM) correlates of childhood trauma in adolescents exposed to childhood maltreatment (N = 379) and unexposed controls (N = 348).MethodsAnisotropic effect size-signed differential mapping (AES-SDM) was utilized to synthesize the studies.ResultsWe observed increased volume amongst adolescents with a history of childhood trauma in regions that are involved in motor functions and language production: left precentral gyrus, including part of the left inferior frontal gyrus, left fibers of the body of corpus callosum, and left postcentral gyrus. We observed decreased volume amongst adolescents with a history of childhood trauma in regions that are involved in language processing and/or sensory processing: bilateral cerebellum, bilateral middle temporal gyrus, left rostrum of corpus callosum, and bilateral supramarginal gyrus.DiscussionWe suggest that these morphometric differences may be reflective of impaired motor development and increased sensory sensitivity and hypervigilance in adolescents with experiences of childhood trauma. Our results differ from meta-analytical findings in adults with history of childhood trauma and may contribute to a better understanding of neural mechanisms of childhood trauma, prediction of neurodevelopmental outcomes, and development of more effective and personalized therapies. |
| first_indexed | 2024-04-11T06:32:58Z |
| format | Article |
| id | doaj.art-b5a2b1844de847d2b97e3d5d44e38b06 |
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| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-11T06:32:58Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-b5a2b1844de847d2b97e3d5d44e38b062022-12-22T04:39:59ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-12-011610.3389/fnhum.2022.10227911022791A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood traumaOlga Tymofiyeva0Rebecca Hu1Rebecca Hu2Roma Kidambi3Ca Nguyen4Jeffrey E. Max5Jeffrey E. Max6Tony T. Yang7Tony T. Yang8Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Psychiatry and Behavioral Sciences, The Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, CA, United StatesDivision of Child and Adolescent Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Psychiatry, University of California, San Diego, San Diego, CA, United StatesRady Children’s Hospital, San Diego, CA, United StatesDepartment of Psychiatry and Behavioral Sciences, The Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, CA, United StatesDivision of Child and Adolescent Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United StatesIntroductionChildhood trauma is known to have dramatic effects on the risks for developing psychiatric disorders and increased suicidality. We conducted a meta-analysis of whole brain voxel-based morphometry (VBM) correlates of childhood trauma in adolescents exposed to childhood maltreatment (N = 379) and unexposed controls (N = 348).MethodsAnisotropic effect size-signed differential mapping (AES-SDM) was utilized to synthesize the studies.ResultsWe observed increased volume amongst adolescents with a history of childhood trauma in regions that are involved in motor functions and language production: left precentral gyrus, including part of the left inferior frontal gyrus, left fibers of the body of corpus callosum, and left postcentral gyrus. We observed decreased volume amongst adolescents with a history of childhood trauma in regions that are involved in language processing and/or sensory processing: bilateral cerebellum, bilateral middle temporal gyrus, left rostrum of corpus callosum, and bilateral supramarginal gyrus.DiscussionWe suggest that these morphometric differences may be reflective of impaired motor development and increased sensory sensitivity and hypervigilance in adolescents with experiences of childhood trauma. Our results differ from meta-analytical findings in adults with history of childhood trauma and may contribute to a better understanding of neural mechanisms of childhood trauma, prediction of neurodevelopmental outcomes, and development of more effective and personalized therapies.https://www.frontiersin.org/articles/10.3389/fnhum.2022.1022791/fullchildhood traumachild maltreatmentadolescent brainVBMbrain development |
| spellingShingle | Olga Tymofiyeva Rebecca Hu Rebecca Hu Roma Kidambi Ca Nguyen Jeffrey E. Max Jeffrey E. Max Tony T. Yang Tony T. Yang A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma Frontiers in Human Neuroscience childhood trauma child maltreatment adolescent brain VBM brain development |
| title | A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma |
| title_full | A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma |
| title_fullStr | A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma |
| title_full_unstemmed | A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma |
| title_short | A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma |
| title_sort | meta analysis of brain morphometric aberrations in adolescents who experienced childhood trauma |
| topic | childhood trauma child maltreatment adolescent brain VBM brain development |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.1022791/full |
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