ROBO1 p.E280* Loses the Inhibitory Effects on the Proliferation and Angiogenesis of Wild-Type ROBO1 in Cholangiocarcinoma by Interrupting SLIT2 Signal

ROBO1 p.E280* Loses the Inhibitory Effects on the Proliferation and Angiogenesis of Wild-Type ROBO1 in Cholangiocarcinoma by Interrupting SLIT2 Signal

BackgroundCholangiocarcinoma (CCA) remains one of the most lethal malignancies with an increasing incidence globally. Through whole-exome sequencing of 67 CCA tissues, we identified new mutated genes in CCA, including MACF1, METTL14, ROBO1, and so on. The study was designed to explore the effects an...

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Bibliographic Details
Main Authors: Tao Zhou, Yaodong Zhang, Yananlan Chen, Jijun Shan, Jifei Wang, Yirui Wang, Jiang Chang, Wangjie Jiang, Ruixiang Chen, Ziyi Wang, Xiaoli Shi, Yue Yu, Changxian Li, Xiangcheng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
cholangiocarcinoma
ROBO1
nonsense mutation
proliferation
angiogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.879963/full

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