Function and mechanism of bispecific antibodies targeting SARS-CoV-2
As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune evasion. This review extensively assesses a spectrum of repre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Cell Insight |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892724000051 |
| _version_ | 1797233991024115712 |
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| author | Zhaohui Li Zengyuan Zhang Steven T. Rosen Mingye Feng |
| author_facet | Zhaohui Li Zengyuan Zhang Steven T. Rosen Mingye Feng |
| author_sort | Zhaohui Li |
| collection | DOAJ |
| description | As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune evasion. This review extensively assesses a spectrum of representative bispecific antibodies targeting SARS-CoV-2, delving into their characteristics, design formats, mechanisms of action, and associated advantages and limitations. The analysis encompasses factors influencing the selection of parental antibodies and strategies for incorporating added benefits in bispecific antibody design. Furthermore, how different classes of parental antibodies contribute to augmenting the broad-spectrum neutralization capability within bispecific antibodies is discussed. In summary, this review presents analyses and discussions aimed at offering valuable insights for shaping future strategies in bispecific antibody design to effectively confront the challenges posed by SARS-CoV-2 and propel advancements in antiviral therapeutic development. |
| first_indexed | 2024-03-08T00:48:16Z |
| format | Article |
| id | doaj.art-b5a4952f5af2440aae968b401023b566 |
| institution | Directory Open Access Journal |
| issn | 2772-8927 |
| language | English |
| last_indexed | 2024-04-24T16:24:57Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj.art-b5a4952f5af2440aae968b401023b5662024-03-31T04:38:14ZengElsevierCell Insight2772-89272024-04-0132100150Function and mechanism of bispecific antibodies targeting SARS-CoV-2Zhaohui Li0Zengyuan Zhang1Steven T. Rosen2Mingye Feng3Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USADepartment of Molecular Microbiology & Immunology, University of Southern California, CA, USABeckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USADepartment of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA; Corresponding author.As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune evasion. This review extensively assesses a spectrum of representative bispecific antibodies targeting SARS-CoV-2, delving into their characteristics, design formats, mechanisms of action, and associated advantages and limitations. The analysis encompasses factors influencing the selection of parental antibodies and strategies for incorporating added benefits in bispecific antibody design. Furthermore, how different classes of parental antibodies contribute to augmenting the broad-spectrum neutralization capability within bispecific antibodies is discussed. In summary, this review presents analyses and discussions aimed at offering valuable insights for shaping future strategies in bispecific antibody design to effectively confront the challenges posed by SARS-CoV-2 and propel advancements in antiviral therapeutic development.http://www.sciencedirect.com/science/article/pii/S2772892724000051SARS-CoV-2Bispecific antibodyFunctionMechanismBreadth |
| spellingShingle | Zhaohui Li Zengyuan Zhang Steven T. Rosen Mingye Feng Function and mechanism of bispecific antibodies targeting SARS-CoV-2 Cell Insight SARS-CoV-2 Bispecific antibody Function Mechanism Breadth |
| title | Function and mechanism of bispecific antibodies targeting SARS-CoV-2 |
| title_full | Function and mechanism of bispecific antibodies targeting SARS-CoV-2 |
| title_fullStr | Function and mechanism of bispecific antibodies targeting SARS-CoV-2 |
| title_full_unstemmed | Function and mechanism of bispecific antibodies targeting SARS-CoV-2 |
| title_short | Function and mechanism of bispecific antibodies targeting SARS-CoV-2 |
| title_sort | function and mechanism of bispecific antibodies targeting sars cov 2 |
| topic | SARS-CoV-2 Bispecific antibody Function Mechanism Breadth |
| url | http://www.sciencedirect.com/science/article/pii/S2772892724000051 |
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