Functions of the extracellular matrix and matrix degrading proteases during tumor progression
Cell interactions with extracellular matrices are important to pathological changes that occur during cell transformation and tumorigenesis. Several extracellular matrix proteins including fibronectin, thrombospondin-1, laminin, SPARC, and osteopontin have been suggested to modulate tumor phenotype...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
1999-07-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700002 |
| _version_ | 1828961979316830208 |
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| author | L. Liaw H.C. Crawford |
| author_facet | L. Liaw H.C. Crawford |
| author_sort | L. Liaw |
| collection | DOAJ |
| description | Cell interactions with extracellular matrices are important to pathological changes that occur during cell transformation and tumorigenesis. Several extracellular matrix proteins including fibronectin, thrombospondin-1, laminin, SPARC, and osteopontin have been suggested to modulate tumor phenotype by affecting cell migration, survival, or angiogenesis. Likewise, proteases including the matrix metalloproteinases (MMPs) are understood to not only facilitate migration of cells by degradation of matrices, but also to affect tumor formation and growth. We have recently demonstrated an in vivo role for the RGD-containing protein, osteopontin, during tumor progression, and found evidence for distinct functions in the host versus the tumor cells. Because of the compartmentalization and temporal regulation of MMP expression, it is likely that MMPs may also function dually in host stroma and the tumor cell. In addition, an important function of proteases appears to be not only degradation, but also cleavage of matrix proteins to generate functionally distinct fragments based on receptor binding, biological activity, or regulation of growth factors. |
| first_indexed | 2024-12-14T09:56:54Z |
| format | Article |
| id | doaj.art-b5a6c05c24654d7d8271cfdb63bd42de |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-14T09:56:54Z |
| publishDate | 1999-07-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-b5a6c05c24654d7d8271cfdb63bd42de2022-12-21T23:07:22ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X1999-07-0132780581210.1590/S0100-879X1999000700002Functions of the extracellular matrix and matrix degrading proteases during tumor progressionL. LiawH.C. CrawfordCell interactions with extracellular matrices are important to pathological changes that occur during cell transformation and tumorigenesis. Several extracellular matrix proteins including fibronectin, thrombospondin-1, laminin, SPARC, and osteopontin have been suggested to modulate tumor phenotype by affecting cell migration, survival, or angiogenesis. Likewise, proteases including the matrix metalloproteinases (MMPs) are understood to not only facilitate migration of cells by degradation of matrices, but also to affect tumor formation and growth. We have recently demonstrated an in vivo role for the RGD-containing protein, osteopontin, during tumor progression, and found evidence for distinct functions in the host versus the tumor cells. Because of the compartmentalization and temporal regulation of MMP expression, it is likely that MMPs may also function dually in host stroma and the tumor cell. In addition, an important function of proteases appears to be not only degradation, but also cleavage of matrix proteins to generate functionally distinct fragments based on receptor binding, biological activity, or regulation of growth factors.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700002matrix metalloproteinaseosteopontincarcinomaprotease |
| spellingShingle | L. Liaw H.C. Crawford Functions of the extracellular matrix and matrix degrading proteases during tumor progression Brazilian Journal of Medical and Biological Research matrix metalloproteinase osteopontin carcinoma protease |
| title | Functions of the extracellular matrix and matrix degrading proteases during tumor progression |
| title_full | Functions of the extracellular matrix and matrix degrading proteases during tumor progression |
| title_fullStr | Functions of the extracellular matrix and matrix degrading proteases during tumor progression |
| title_full_unstemmed | Functions of the extracellular matrix and matrix degrading proteases during tumor progression |
| title_short | Functions of the extracellular matrix and matrix degrading proteases during tumor progression |
| title_sort | functions of the extracellular matrix and matrix degrading proteases during tumor progression |
| topic | matrix metalloproteinase osteopontin carcinoma protease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700002 |
| work_keys_str_mv | AT lliaw functionsoftheextracellularmatrixandmatrixdegradingproteasesduringtumorprogression AT hccrawford functionsoftheextracellularmatrixandmatrixdegradingproteasesduringtumorprogression |