NecroX-5 ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3-mediated epithelial–mesenchymal transition

NecroX-5 ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3-mediated epithelial–mesenchymal transition

Abstract Background Pulmonary fibrosis is a progressive and usually lethal pulmonary disease. Despite considerable research efforts, no effective therapeutic strategy for pulmonary fibrosis has been developed. NecroX-5 has been reported to possess anti-inflammatory, anti-oxidative and anti-tumor act...

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Bibliographic Details
Main Authors: Li Min, Zhang Shu-Li, Yuan Feng, Hu Han, Li Shao-Jun, Tong Sheng-Xiong, Tian Jia-Yu, Fang Xiang-Zhi, Feng Dan
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Respiratory Research
Subjects:
NecroX-5
Lung injury
Fibrosis
EMT
NLRP3
Online Access:https://doi.org/10.1186/s12931-022-02044-3

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