Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China
Abstract Background and aims Manganese (Mn) deficiency and intoxication may affect nonalcoholic fatty liver disease (NAFLD) risk differently. We aimed to explore the association between blood Mn and NAFLD in an area with high Mn exposure in drinking water. Methods We conducted a case–control study a...
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| Language: | English |
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BMC
2023-11-01
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| Series: | Journal of Health, Population and Nutrition |
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| Online Access: | https://doi.org/10.1186/s41043-023-00467-2 |
| _version_ | 1797630186528702464 |
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| author | Liping Wu Yanqi Lan Ze Yu Yanhong Wang Wei Liao Guoqiang Zhang Li Wang |
| author_facet | Liping Wu Yanqi Lan Ze Yu Yanhong Wang Wei Liao Guoqiang Zhang Li Wang |
| author_sort | Liping Wu |
| collection | DOAJ |
| description | Abstract Background and aims Manganese (Mn) deficiency and intoxication may affect nonalcoholic fatty liver disease (NAFLD) risk differently. We aimed to explore the association between blood Mn and NAFLD in an area with high Mn exposure in drinking water. Methods We conducted a case–control study among 1407 patients with NAFLD and 1774 sex- and age-matched healthy controls in a physical examination population in Zhoushan hospital, Zhejiang province in China. We used the restricted cubic splines method to investigate the dose–response relationship. Logistic regression models were applied to determine the risk of NAFLD, and severity of NAFLD. Results The blood Mn concentration was higher in the NAFLD group than in the control group in women (16.1 ± 6.2 μg/L vs. 14.7 ± 6.4 μg/L, P = 0.022) and men (14.5 ± 6.3 μg/L vs. 13.6 ± 6.8 μg/L, P < 0.001). We found an inverted L shape relationship between blood Mn and NAFLD in both women and men. Compared to the lowest quartile, the adjusted odds ratio (OR) and 95% confidence interval (CI) of NAFLD for the highest quartile group was 1.646(1.222,2.217), 1.494(1.082,2.061), and 3.146(1.285,7.701) for the total population, men, and women. The positive relationship was only observed in those with fibrosis-4 score < 1.30 and normal alanine transaminase. Stratified analysis showed an interaction between smoking (P = 0.073), alcohol drinking (P = 0.013), and Mn, with a more prominent effect on the NAFLD in the never-smokers (OR = 2.153, 95% CI 1.408–3.290) and drinkers (OR = 2.596, 95% CI 1.608–4.191). Conclusion Higher blood Mn is associated with an elevated NAFLD risk in the high Mn exposure areas, especially in nonsmokers and drinkers. Further studies are needed to verify this result in the areas with high Mn exposure. |
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| institution | Directory Open Access Journal |
| issn | 2072-1315 |
| language | English |
| last_indexed | 2024-03-11T11:03:30Z |
| publishDate | 2023-11-01 |
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| series | Journal of Health, Population and Nutrition |
| spelling | doaj.art-b5a86601af4a45108b2659a9fccce2e42023-11-12T12:21:21ZengBMCJournal of Health, Population and Nutrition2072-13152023-11-014211910.1186/s41043-023-00467-2Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in ChinaLiping Wu0Yanqi Lan1Ze Yu2Yanhong Wang3Wei Liao4Guoqiang Zhang5Li Wang6Department of Hepatobiliary Surgery, Zhoushan Hospital, Wenzhou Medical UniversityDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking, Union Medical CollegeDepartment of Hepatobiliary Surgery, Zhoushan Hospital, Wenzhou Medical UniversityDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking, Union Medical CollegeDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking, Union Medical CollegeDepartment of Hepatobiliary Surgery, Zhoushan Hospital, Wenzhou Medical UniversityDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking, Union Medical CollegeAbstract Background and aims Manganese (Mn) deficiency and intoxication may affect nonalcoholic fatty liver disease (NAFLD) risk differently. We aimed to explore the association between blood Mn and NAFLD in an area with high Mn exposure in drinking water. Methods We conducted a case–control study among 1407 patients with NAFLD and 1774 sex- and age-matched healthy controls in a physical examination population in Zhoushan hospital, Zhejiang province in China. We used the restricted cubic splines method to investigate the dose–response relationship. Logistic regression models were applied to determine the risk of NAFLD, and severity of NAFLD. Results The blood Mn concentration was higher in the NAFLD group than in the control group in women (16.1 ± 6.2 μg/L vs. 14.7 ± 6.4 μg/L, P = 0.022) and men (14.5 ± 6.3 μg/L vs. 13.6 ± 6.8 μg/L, P < 0.001). We found an inverted L shape relationship between blood Mn and NAFLD in both women and men. Compared to the lowest quartile, the adjusted odds ratio (OR) and 95% confidence interval (CI) of NAFLD for the highest quartile group was 1.646(1.222,2.217), 1.494(1.082,2.061), and 3.146(1.285,7.701) for the total population, men, and women. The positive relationship was only observed in those with fibrosis-4 score < 1.30 and normal alanine transaminase. Stratified analysis showed an interaction between smoking (P = 0.073), alcohol drinking (P = 0.013), and Mn, with a more prominent effect on the NAFLD in the never-smokers (OR = 2.153, 95% CI 1.408–3.290) and drinkers (OR = 2.596, 95% CI 1.608–4.191). Conclusion Higher blood Mn is associated with an elevated NAFLD risk in the high Mn exposure areas, especially in nonsmokers and drinkers. Further studies are needed to verify this result in the areas with high Mn exposure.https://doi.org/10.1186/s41043-023-00467-2NAFLDManganeseCase–control studyHigh manganese exposure area |
| spellingShingle | Liping Wu Yanqi Lan Ze Yu Yanhong Wang Wei Liao Guoqiang Zhang Li Wang Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China Journal of Health, Population and Nutrition NAFLD Manganese Case–control study High manganese exposure area |
| title | Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China |
| title_full | Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China |
| title_fullStr | Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China |
| title_full_unstemmed | Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China |
| title_short | Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China |
| title_sort | blood manganese and non alcoholic fatty liver disease in a high manganese exposure area in china |
| topic | NAFLD Manganese Case–control study High manganese exposure area |
| url | https://doi.org/10.1186/s41043-023-00467-2 |
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