An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributes
Chinese Skullcap (Scutellaria baicalensis) is a traditional medicinal herb with a rich history of use in Traditional Chinese Medicine (TCM). This review aims to provide an updated overview of the phytochemical constituents and pharmacological attributes of Chinese Skullcap, shedding light on its pot...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142523001124 |
| _version_ | 1797388630418784256 |
|---|---|
| author | Dilip Kumar Chanchal Kuldeep Singh Bharat Bhushan Jitendra Singh Chaudhary Shivendra Kumar Ajit Kumar Varma Neha Agnihotri Akash Garg |
| author_facet | Dilip Kumar Chanchal Kuldeep Singh Bharat Bhushan Jitendra Singh Chaudhary Shivendra Kumar Ajit Kumar Varma Neha Agnihotri Akash Garg |
| author_sort | Dilip Kumar Chanchal |
| collection | DOAJ |
| description | Chinese Skullcap (Scutellaria baicalensis) is a traditional medicinal herb with a rich history of use in Traditional Chinese Medicine (TCM). This review aims to provide an updated overview of the phytochemical constituents and pharmacological attributes of Chinese Skullcap, shedding light on its potential therapeutic applications. A comprehensive search of scientific databases, including PubMed, Scopus, and Web of Science, was conducted to gather relevant literature published up to September 2023. Keywords such as ''Scutellaria baicalensis,'' ''phytochemicals,'' and ''pharmacological properties'' were used to identify pertinent studies. Chinese Skullcap was found to contain a diverse array of phytochemical constituents, including flavonoids, alkaloids, and terpenoids, with baicalin and baicalein being the most prominent bioactive compounds. These compounds have demonstrated a wide range of pharmacological activities, including anti-inflammatory, antioxidant, anti-cancer, neuroprotective, and hepatoprotective effects. Additionally, Chinese Skullcap has been investigated for its potential in treating various diseases, such as cancer, cardiovascular disorders, and neurodegenerative conditions. Chinese Skullcap represents a compelling avenue for future therapeutic development, emphasizing the ongoing need for scientific exploration and clinical investigation. |
| first_indexed | 2024-03-08T22:43:34Z |
| format | Article |
| id | doaj.art-b5ac3c439a124f0d9d69b4ec8c7a232c |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-03-08T22:43:34Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-b5ac3c439a124f0d9d69b4ec8c7a232c2023-12-17T06:43:00ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252023-12-019100326An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributesDilip Kumar Chanchal0Kuldeep Singh1Bharat Bhushan2Jitendra Singh Chaudhary3Shivendra Kumar4Ajit Kumar Varma5Neha Agnihotri6Akash Garg7Department of Pharmacognosy, Smt. Vidyawati College of Pharmacy, Jhansi, Uttar Pradesh, IndiaDepartment of Pharmacology, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh, India; Corresponding author.Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura Uttar Pradesh, IndiaDepartment of Pharmaceutics, Smt. Vidyawati College of Pharmacy, Jhansi, Uttar Pradesh, IndiaDepartment of Pharmacology, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh, IndiaDepartment of Pharmaceutics, Rama University, Mandhana, Kanpur, Uttar Pradesh, IndiaDepartment of Pharmaceutics, Maharana Pratap College of Pharmacy, Kothi, Mandhana, Kanpur, Uttar Pradesh, IndiaDepartment of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh, IndiaChinese Skullcap (Scutellaria baicalensis) is a traditional medicinal herb with a rich history of use in Traditional Chinese Medicine (TCM). This review aims to provide an updated overview of the phytochemical constituents and pharmacological attributes of Chinese Skullcap, shedding light on its potential therapeutic applications. A comprehensive search of scientific databases, including PubMed, Scopus, and Web of Science, was conducted to gather relevant literature published up to September 2023. Keywords such as ''Scutellaria baicalensis,'' ''phytochemicals,'' and ''pharmacological properties'' were used to identify pertinent studies. Chinese Skullcap was found to contain a diverse array of phytochemical constituents, including flavonoids, alkaloids, and terpenoids, with baicalin and baicalein being the most prominent bioactive compounds. These compounds have demonstrated a wide range of pharmacological activities, including anti-inflammatory, antioxidant, anti-cancer, neuroprotective, and hepatoprotective effects. Additionally, Chinese Skullcap has been investigated for its potential in treating various diseases, such as cancer, cardiovascular disorders, and neurodegenerative conditions. Chinese Skullcap represents a compelling avenue for future therapeutic development, emphasizing the ongoing need for scientific exploration and clinical investigation.http://www.sciencedirect.com/science/article/pii/S2667142523001124Chinese skullcap (Scutellaria baicalensis)PhytochemicalsFlavonoidsAnti-inflammatoryAntioxidantNeuroprotection |
| spellingShingle | Dilip Kumar Chanchal Kuldeep Singh Bharat Bhushan Jitendra Singh Chaudhary Shivendra Kumar Ajit Kumar Varma Neha Agnihotri Akash Garg An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributes Pharmacological Research - Modern Chinese Medicine Chinese skullcap (Scutellaria baicalensis) Phytochemicals Flavonoids Anti-inflammatory Antioxidant Neuroprotection |
| title | An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributes |
| title_full | An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributes |
| title_fullStr | An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributes |
| title_full_unstemmed | An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributes |
| title_short | An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributes |
| title_sort | updated review of chinese skullcap scutellaria baicalensis emphasis on phytochemical constituents and pharmacological attributes |
| topic | Chinese skullcap (Scutellaria baicalensis) Phytochemicals Flavonoids Anti-inflammatory Antioxidant Neuroprotection |
| url | http://www.sciencedirect.com/science/article/pii/S2667142523001124 |
| work_keys_str_mv | AT dilipkumarchanchal anupdatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT kuldeepsingh anupdatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT bharatbhushan anupdatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT jitendrasinghchaudhary anupdatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT shivendrakumar anupdatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT ajitkumarvarma anupdatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT nehaagnihotri anupdatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT akashgarg anupdatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT dilipkumarchanchal updatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT kuldeepsingh updatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT bharatbhushan updatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT jitendrasinghchaudhary updatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT shivendrakumar updatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT ajitkumarvarma updatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT nehaagnihotri updatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes AT akashgarg updatedreviewofchineseskullcapscutellariabaicalensisemphasisonphytochemicalconstituentsandpharmacologicalattributes |