OX40 agonist stimulation increases and sustains humoral and cell-mediated responses to SARS-CoV-2 protein and saRNA vaccines

OX40 agonist stimulation increases and sustains humoral and cell-mediated responses to SARS-CoV-2 protein and saRNA vaccines

To prevent SARS-CoV-2 infections and generate long-lasting immunity, vaccines need to generate strong viral-specific B and T cell responses. Previous results from our lab and others have shown that immunizations in the presence of an OX40 agonist antibody lead to higher antibody titers and increased...

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Bibliographic Details
Main Authors: Rebekka Duhen, Michael Beymer, Shawn M. Jensen, Srinivas Abbina, Suraj Abraham, Nikita Jain, Anitha Thomas, Andrew J. Geall, Hong-Ming Hu, Bernard A. Fox, Andrew D. Weinberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
ANTI-OX40
co-stimulation
sa-RNA vaccine
T cell activation
SARS-CoV-2 vaccine
protein vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.896310/full

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