Synthesis, Identification and Anti-candidaProperties of Some NewBis (Five, Six, Seven-membered Heterocycles) AttachedPyrrole Rings
This research involves preparation of many bisheterocycles attached to pyrrole rings have been synthesized by the stepwise procedure such asbis(1,2-dihydropyridazine-3,6-dione) (3),bis(2,3dihydrophthalazine-1,4-dione) (4) and bis(tetrahydropyridazine-3,6-dione) (5) derivatives of pyrrole. Further t...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2018-03-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
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| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/74 |
| _version_ | 1797223946124263424 |
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| author | Ayad Kareem Khan |
| author_facet | Ayad Kareem Khan |
| author_sort | Ayad Kareem Khan |
| collection | DOAJ |
| description |
This research involves preparation of many bisheterocycles attached to pyrrole rings have been synthesized by the stepwise procedure such asbis(1,2-dihydropyridazine-3,6-dione) (3),bis(2,3dihydrophthalazine-1,4-dione) (4) and bis(tetrahydropyridazine-3,6-dione) (5) derivatives of pyrrole. Further the bis(3,5-dimethyl-1H-pyrazol-1-yl)methanone (6), bis(3-methyl-1H-pyrazol5(4H)-one) (7) and bis(4H-1,3,4-oxadiazin-6(5H)-one) (8) pyrrole derivatives also prepared in good yields. Furthermore, series of bis-benzothiazine (10a-c), bis-benzoxathiazepine (11a-c)and bis-quinazoline compounds (12a-c) attached to pyrrole moieties also have been synthesized successfully.Structures of the newly synthesized compounds were established by physicochemical, elemental analysis CHNS, FTIR, H-NMR and C-NMR spectroscopic methods. The new synthesized agents were evaluated for their in vitro inhibitory effectagainst several candida isolates. Some of the evaluated compounds possessed good activities compared to a fluconazole, nystatin and clotrimazole standard antifungal drugs.
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| first_indexed | 2024-04-24T13:45:18Z |
| format | Article |
| id | doaj.art-b5ad1567749f470782d28f94b82b2eca |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:45:18Z |
| publishDate | 2018-03-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-b5ad1567749f470782d28f94b82b2eca2024-04-04T06:58:08ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2018-03-0117110.32947/ajps.v17i1.74Synthesis, Identification and Anti-candidaProperties of Some NewBis (Five, Six, Seven-membered Heterocycles) AttachedPyrrole RingsAyad Kareem Khan0Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq This research involves preparation of many bisheterocycles attached to pyrrole rings have been synthesized by the stepwise procedure such asbis(1,2-dihydropyridazine-3,6-dione) (3),bis(2,3dihydrophthalazine-1,4-dione) (4) and bis(tetrahydropyridazine-3,6-dione) (5) derivatives of pyrrole. Further the bis(3,5-dimethyl-1H-pyrazol-1-yl)methanone (6), bis(3-methyl-1H-pyrazol5(4H)-one) (7) and bis(4H-1,3,4-oxadiazin-6(5H)-one) (8) pyrrole derivatives also prepared in good yields. Furthermore, series of bis-benzothiazine (10a-c), bis-benzoxathiazepine (11a-c)and bis-quinazoline compounds (12a-c) attached to pyrrole moieties also have been synthesized successfully.Structures of the newly synthesized compounds were established by physicochemical, elemental analysis CHNS, FTIR, H-NMR and C-NMR spectroscopic methods. The new synthesized agents were evaluated for their in vitro inhibitory effectagainst several candida isolates. Some of the evaluated compounds possessed good activities compared to a fluconazole, nystatin and clotrimazole standard antifungal drugs. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/74Synthesiidentificationanti-candidabis heterocyclespyrrole rings |
| spellingShingle | Ayad Kareem Khan Synthesis, Identification and Anti-candidaProperties of Some NewBis (Five, Six, Seven-membered Heterocycles) AttachedPyrrole Rings Al-Mustansiriyah Journal of Pharmaceutical Sciences Synthesi identification anti-candida bis heterocycles pyrrole rings |
| title | Synthesis, Identification and Anti-candidaProperties of Some NewBis (Five, Six, Seven-membered Heterocycles) AttachedPyrrole Rings |
| title_full | Synthesis, Identification and Anti-candidaProperties of Some NewBis (Five, Six, Seven-membered Heterocycles) AttachedPyrrole Rings |
| title_fullStr | Synthesis, Identification and Anti-candidaProperties of Some NewBis (Five, Six, Seven-membered Heterocycles) AttachedPyrrole Rings |
| title_full_unstemmed | Synthesis, Identification and Anti-candidaProperties of Some NewBis (Five, Six, Seven-membered Heterocycles) AttachedPyrrole Rings |
| title_short | Synthesis, Identification and Anti-candidaProperties of Some NewBis (Five, Six, Seven-membered Heterocycles) AttachedPyrrole Rings |
| title_sort | synthesis identification and anti candidaproperties of some newbis five six seven membered heterocycles attachedpyrrole rings |
| topic | Synthesi identification anti-candida bis heterocycles pyrrole rings |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/74 |
| work_keys_str_mv | AT ayadkareemkhan synthesisidentificationandanticandidapropertiesofsomenewbisfivesixsevenmemberedheterocyclesattachedpyrrolerings |