Case Report: Cytologic Description of Somatotroph Pituitary Adenoma in a Cat
This case report describes for the first time the cytologic characteristics of a hormonally secreting pituitary adenoma in a cat. An 8-year-old female spayed domestic long-haired cat was referred with a previous diagnosis of hypersomatotropism and secondary diabetes mellitus 7 months prior. Clinical...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.934009/full |
| _version_ | 1828269847356637184 |
|---|---|
| author | Flavio H. Alonso Flavio H. Alonso Kevin D. Niedringhaus Mariah G. Ceregatti Marisa A. Maglaty |
| author_facet | Flavio H. Alonso Flavio H. Alonso Kevin D. Niedringhaus Mariah G. Ceregatti Marisa A. Maglaty |
| author_sort | Flavio H. Alonso |
| collection | DOAJ |
| description | This case report describes for the first time the cytologic characteristics of a hormonally secreting pituitary adenoma in a cat. An 8-year-old female spayed domestic long-haired cat was referred with a previous diagnosis of hypersomatotropism and secondary diabetes mellitus 7 months prior. Clinical signs included weight loss, polyphagia, polyuria, and polydipsia. Serum insulin-like growth factor-1 was 340 nmol/L (RI: 12-92), and CT scan revealed a hypophyseal mass, and a presumptive diagnosis of acromegaly was made. A transsphenoidal hypophysectomy was performed. A fragment of the pituitary gland was subjected to a squash preparation and cytology revealed a neuroendocrine neoplasm characterized by anisokaryosis and prominent nucleoli. Additional cytologic findings included cell cohesiveness, indistinct cytoplasmic borders, nuclear crowding, molding, and fragmentation. A diagnosis of adenoma was based on a lack of histopathologic or imaging evidence of invasion. A week later, during post-surgical hospitalization, the patient worsened and died. Histopathology from a necropsy procedure revealed fibrinosuppurative meningitis as a post-surgical complication. Pituitary adenomas might have an aggressive cytologic appearance, despite a lack of histopathologic invasion or dissemination. |
| first_indexed | 2024-04-13T05:34:13Z |
| format | Article |
| id | doaj.art-b5ad2d20622f41f68d2687fd74541c3c |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-13T05:34:13Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-b5ad2d20622f41f68d2687fd74541c3c2022-12-22T03:00:20ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-07-01910.3389/fvets.2022.934009934009Case Report: Cytologic Description of Somatotroph Pituitary Adenoma in a CatFlavio H. Alonso0Flavio H. Alonso1Kevin D. Niedringhaus2Mariah G. Ceregatti3Marisa A. Maglaty4Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, CA, United StatesDepartment of Biomedical Sciences, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and NevisVeterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, CA, United StatesDepartment of Veterinary Clinic and Surgery, School of Veterinary Medicine, Federal University of Minas Gerais, Belo Horizonte, BrazilVeterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, CA, United StatesThis case report describes for the first time the cytologic characteristics of a hormonally secreting pituitary adenoma in a cat. An 8-year-old female spayed domestic long-haired cat was referred with a previous diagnosis of hypersomatotropism and secondary diabetes mellitus 7 months prior. Clinical signs included weight loss, polyphagia, polyuria, and polydipsia. Serum insulin-like growth factor-1 was 340 nmol/L (RI: 12-92), and CT scan revealed a hypophyseal mass, and a presumptive diagnosis of acromegaly was made. A transsphenoidal hypophysectomy was performed. A fragment of the pituitary gland was subjected to a squash preparation and cytology revealed a neuroendocrine neoplasm characterized by anisokaryosis and prominent nucleoli. Additional cytologic findings included cell cohesiveness, indistinct cytoplasmic borders, nuclear crowding, molding, and fragmentation. A diagnosis of adenoma was based on a lack of histopathologic or imaging evidence of invasion. A week later, during post-surgical hospitalization, the patient worsened and died. Histopathology from a necropsy procedure revealed fibrinosuppurative meningitis as a post-surgical complication. Pituitary adenomas might have an aggressive cytologic appearance, despite a lack of histopathologic invasion or dissemination.https://www.frontiersin.org/articles/10.3389/fvets.2022.934009/fullbrainhistopathologycentral hypothyroidismhypophysisdiabetes mellitus |
| spellingShingle | Flavio H. Alonso Flavio H. Alonso Kevin D. Niedringhaus Mariah G. Ceregatti Marisa A. Maglaty Case Report: Cytologic Description of Somatotroph Pituitary Adenoma in a Cat Frontiers in Veterinary Science brain histopathology central hypothyroidism hypophysis diabetes mellitus |
| title | Case Report: Cytologic Description of Somatotroph Pituitary Adenoma in a Cat |
| title_full | Case Report: Cytologic Description of Somatotroph Pituitary Adenoma in a Cat |
| title_fullStr | Case Report: Cytologic Description of Somatotroph Pituitary Adenoma in a Cat |
| title_full_unstemmed | Case Report: Cytologic Description of Somatotroph Pituitary Adenoma in a Cat |
| title_short | Case Report: Cytologic Description of Somatotroph Pituitary Adenoma in a Cat |
| title_sort | case report cytologic description of somatotroph pituitary adenoma in a cat |
| topic | brain histopathology central hypothyroidism hypophysis diabetes mellitus |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.934009/full |
| work_keys_str_mv | AT flaviohalonso casereportcytologicdescriptionofsomatotrophpituitaryadenomainacat AT flaviohalonso casereportcytologicdescriptionofsomatotrophpituitaryadenomainacat AT kevindniedringhaus casereportcytologicdescriptionofsomatotrophpituitaryadenomainacat AT mariahgceregatti casereportcytologicdescriptionofsomatotrophpituitaryadenomainacat AT marisaamaglaty casereportcytologicdescriptionofsomatotrophpituitaryadenomainacat |