Persistent but atypical germinal center reaction among 3rd SARS-CoV-2 vaccination after rituximab exposure

Persistent but atypical germinal center reaction among 3rd SARS-CoV-2 vaccination after rituximab exposure

BackgroundDurable vaccine-mediated immunity relies on the generation of long-lived plasma cells and memory B cells (MBCs), differentiating upon germinal center (GC) reactions. SARS-CoV-2 mRNA vaccination induces a strong GC response in healthy volunteers (HC), but limited data is available about res...

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Bibliographic Details
Main Authors: Ana-Luisa Stefanski, Hector Rincon-Arevalo, Eva Schrezenmeier, Kirsten Karberg, Franziska Szelinski, Jacob Ritter, Yidan Chen, Christian Meisel, Bernd Jahrsdörfer, Carolin Ludwig, Hubert Schrezenmeier, Andreia C. Lino, Thomas Dörner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
rituximab (RTX)
SARS-CoV-2
vaccination
memory B cell (MBC)
germinal center (GC)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.943476/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.943476/full

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