Bidirectional association between depression and diabetic nephropathy by meta-analysis.
<h4>Background</h4>Studies suggested that the association between depression and diabetic nephropathy may be bi-directional, but this hypothesis remains investigating. In this meta-analysis, the bi-directional relationship between depression and diabetic nephropathy was investigated.<...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0278489 |
| _version_ | 1797954044437725184 |
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| author | Tingting Fang Qiuling Zhang Zhiguo Wang Jun-Ping Liu |
| author_facet | Tingting Fang Qiuling Zhang Zhiguo Wang Jun-Ping Liu |
| author_sort | Tingting Fang |
| collection | DOAJ |
| description | <h4>Background</h4>Studies suggested that the association between depression and diabetic nephropathy may be bi-directional, but this hypothesis remains investigating. In this meta-analysis, the bi-directional relationship between depression and diabetic nephropathy was investigated.<h4>Methods</h4>A search for the publications on depression and diabetic nephropathy in the databases of PubMed, Web of science, and Embase from the earliest available to August 2022 was conducted. Two sets of pooled risk estimates were calculated using random effects models: diabetic nephropathy predicting depression and depression predicting diabetic nephropathy. Cross-sectional studies were assessed using Agency for Healthcare Research and Quality (AHRQ), cohort and case-control studies were assessed using Newcastle-Ottawa Scale (NOS).<h4>Result</h4>Of the 974,121 patients in 30 clinical studies, 24 studies met eligibility for diabetic nephropathy predicting onset of depression, representing 28,438 incident cases. The other 6 studies met criteria for depression predicting onset of diabetic nephropathy, representing 945,683 incident cases. The pooled odds ratio (OR) of diabetic nephropathy predicting depression was 1.46 (95% CI 1.27-1.67). The OR of depression predicting diabetic nephropathy was 1.22 (95% CI 1.13-1.31).<h4>Conclusion</h4>This meta-analysis shows that the relationship between depression and diabetic nephropathy may be bidirectional. Diabetic nephropathy may be a predictor of depression, and depression may also be an indicator of diabetic nephropathy. The mechanisms underlying the bidirectional relationship need to be further investigated and interventions of the comorbidity of depression and diabetic nephropathy need be studied in clinical practice. |
| first_indexed | 2024-04-10T23:11:27Z |
| format | Article |
| id | doaj.art-b5b0524800fb4ae69b99f6e69a6163db |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T23:11:27Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b5b0524800fb4ae69b99f6e69a6163db2023-01-13T05:31:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011712e027848910.1371/journal.pone.0278489Bidirectional association between depression and diabetic nephropathy by meta-analysis.Tingting FangQiuling ZhangZhiguo WangJun-Ping Liu<h4>Background</h4>Studies suggested that the association between depression and diabetic nephropathy may be bi-directional, but this hypothesis remains investigating. In this meta-analysis, the bi-directional relationship between depression and diabetic nephropathy was investigated.<h4>Methods</h4>A search for the publications on depression and diabetic nephropathy in the databases of PubMed, Web of science, and Embase from the earliest available to August 2022 was conducted. Two sets of pooled risk estimates were calculated using random effects models: diabetic nephropathy predicting depression and depression predicting diabetic nephropathy. Cross-sectional studies were assessed using Agency for Healthcare Research and Quality (AHRQ), cohort and case-control studies were assessed using Newcastle-Ottawa Scale (NOS).<h4>Result</h4>Of the 974,121 patients in 30 clinical studies, 24 studies met eligibility for diabetic nephropathy predicting onset of depression, representing 28,438 incident cases. The other 6 studies met criteria for depression predicting onset of diabetic nephropathy, representing 945,683 incident cases. The pooled odds ratio (OR) of diabetic nephropathy predicting depression was 1.46 (95% CI 1.27-1.67). The OR of depression predicting diabetic nephropathy was 1.22 (95% CI 1.13-1.31).<h4>Conclusion</h4>This meta-analysis shows that the relationship between depression and diabetic nephropathy may be bidirectional. Diabetic nephropathy may be a predictor of depression, and depression may also be an indicator of diabetic nephropathy. The mechanisms underlying the bidirectional relationship need to be further investigated and interventions of the comorbidity of depression and diabetic nephropathy need be studied in clinical practice.https://doi.org/10.1371/journal.pone.0278489 |
| spellingShingle | Tingting Fang Qiuling Zhang Zhiguo Wang Jun-Ping Liu Bidirectional association between depression and diabetic nephropathy by meta-analysis. PLoS ONE |
| title | Bidirectional association between depression and diabetic nephropathy by meta-analysis. |
| title_full | Bidirectional association between depression and diabetic nephropathy by meta-analysis. |
| title_fullStr | Bidirectional association between depression and diabetic nephropathy by meta-analysis. |
| title_full_unstemmed | Bidirectional association between depression and diabetic nephropathy by meta-analysis. |
| title_short | Bidirectional association between depression and diabetic nephropathy by meta-analysis. |
| title_sort | bidirectional association between depression and diabetic nephropathy by meta analysis |
| url | https://doi.org/10.1371/journal.pone.0278489 |
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