The Potential of Metabolomics in the Diagnosis of Thyroid Cancer
Thyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current gold standard for diagnosis of thyroid cancer, but drawbacks to this technique in...
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/15/5272 |
| _version_ | 1797561393880236032 |
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| author | Margarida Coelho Luis Raposo Brian J. Goodfellow Luigi Atzori John Jones Bruno Manadas |
| author_facet | Margarida Coelho Luis Raposo Brian J. Goodfellow Luigi Atzori John Jones Bruno Manadas |
| author_sort | Margarida Coelho |
| collection | DOAJ |
| description | Thyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current gold standard for diagnosis of thyroid cancer, but drawbacks to this technique include indeterminate results or an inability to discriminate different carcinomas, thereby requiring additional surgical procedures to obtain a final diagnosis. It is, therefore, necessary to seek more reliable markers to complement and improve current methods. “Omics” approaches have gained much attention in the last decade in the field of biomarker discovery for diagnostic and prognostic characterisation of various pathophysiological conditions. Metabolomics, in particular, has the potential to identify molecular markers of thyroid cancer and identify novel metabolic profiles of the disease, which can, in turn, help in the classification of pathological conditions and lead to a more personalised therapy, assisting in the diagnosis and in the prediction of cancer behaviour. This review considers the current results in thyroid cancer biomarker research with a focus on metabolomics. |
| first_indexed | 2024-03-10T18:14:19Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:14:19Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b5b21ce03fa549bc832cc326eb6f0be92023-11-20T07:53:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012115527210.3390/ijms21155272The Potential of Metabolomics in the Diagnosis of Thyroid CancerMargarida Coelho0Luis Raposo1Brian J. Goodfellow2Luigi Atzori3John Jones4Bruno Manadas5CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, PortugalThyroid Study Group, Portuguese Society of Endocrinology, Diabetes and Metabolism, 1600-892 Lisbon, PortugalDepartment of Chemistry and CICECO, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Biomedical Sciences, University of Cagliari, 09042 Cagliari, ItalyCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, PortugalCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, PortugalThyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current gold standard for diagnosis of thyroid cancer, but drawbacks to this technique include indeterminate results or an inability to discriminate different carcinomas, thereby requiring additional surgical procedures to obtain a final diagnosis. It is, therefore, necessary to seek more reliable markers to complement and improve current methods. “Omics” approaches have gained much attention in the last decade in the field of biomarker discovery for diagnostic and prognostic characterisation of various pathophysiological conditions. Metabolomics, in particular, has the potential to identify molecular markers of thyroid cancer and identify novel metabolic profiles of the disease, which can, in turn, help in the classification of pathological conditions and lead to a more personalised therapy, assisting in the diagnosis and in the prediction of cancer behaviour. This review considers the current results in thyroid cancer biomarker research with a focus on metabolomics.https://www.mdpi.com/1422-0067/21/15/5272metabolomicsthyroid cancerbiomarkermetabolitediagnosis |
| spellingShingle | Margarida Coelho Luis Raposo Brian J. Goodfellow Luigi Atzori John Jones Bruno Manadas The Potential of Metabolomics in the Diagnosis of Thyroid Cancer International Journal of Molecular Sciences metabolomics thyroid cancer biomarker metabolite diagnosis |
| title | The Potential of Metabolomics in the Diagnosis of Thyroid Cancer |
| title_full | The Potential of Metabolomics in the Diagnosis of Thyroid Cancer |
| title_fullStr | The Potential of Metabolomics in the Diagnosis of Thyroid Cancer |
| title_full_unstemmed | The Potential of Metabolomics in the Diagnosis of Thyroid Cancer |
| title_short | The Potential of Metabolomics in the Diagnosis of Thyroid Cancer |
| title_sort | potential of metabolomics in the diagnosis of thyroid cancer |
| topic | metabolomics thyroid cancer biomarker metabolite diagnosis |
| url | https://www.mdpi.com/1422-0067/21/15/5272 |
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