Difference of DNA Compaction Performed by Two kinds of Oncopterin-Mimic Pteridine - Polyamine Conjugates
Two types of pteridine - polyamine conjugates designed on oncopterin perform different actions to DNA. The most obvious difference is their actions in DNA compaction. One of the pteridine - polyamine conjugates, PT- 2R, containing a polyamine substituent (R) on the C(2) position of pterin (PT) compa...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2006-02-01
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| Series: | Pteridines |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pteridines.2006.17.1.1 |
| Summary: | Two types of pteridine - polyamine conjugates designed on oncopterin perform different actions to DNA. The most obvious difference is their actions in DNA compaction. One of the pteridine - polyamine conjugates, PT- 2R, containing a polyamine substituent (R) on the C(2) position of pterin (PT) compacts a DNA molcculc in an all-or-none fashion without the intervention of an intermediate. The othcr (PT-4R: R exists on the c(4) position of PT) carries out the DNA compaction via partially compacted intermediates. The difference is discussed based on various interaction modes of the pteridine - polyamine conjugates to DNA. |
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| ISSN: | 0933-4807 2195-4720 |