Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis

Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis

Macrophages play critical roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). However, it is unclear which macrophage subsets are critically involved in the development of inflammation and fibrosis in NASH. In TSNO mice fed a high-fat/cholesterol/cholate-based diet, which exhibit adva...

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Bibliographic Details
Main Authors: Yuki Tada, Kaichi Kasai, Nana Makiuchi, Naoya Igarashi, Koudai Kani, Shun Takano, Hiroe Honda, Tsutomu Yanagibashi, Yasuharu Watanabe, Fumitake Usui-Kawanishi, Yukihiro Furusawa, Mayuko Ichimura-Shimizu, Yoshiaki Tabuchi, Kiyoshi Takatsu, Koichi Tsuneyama, Yoshinori Nagai
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
Kupffer cell
fibrosis
inflammation
macrophage
non-alcoholic fatty liver disease
non-alcoholic steatohepatitis
Online Access:https://www.mdpi.com/1422-0067/23/21/13251

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