Genome tectonics: linking dynamic genome organization with cellular nutrient
Background: Our daily intake of food provides nutrients for the maintenance of health, growth and development. The field of nutrigenomics aims to link dietary intake/nutrients to changes in epigenetic status and gene expression. Summary: Although the relationship between our diet and our genes in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2022-11-01
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| Series: | Lifestyle Genomics |
| Online Access: | https://www.karger.com/Article/FullText/528011 |
| _version_ | 1811300759833149440 |
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| author | Morgan Fleming Fina Nelson Iain Wallace Christopher H. Eskiw |
| author_facet | Morgan Fleming Fina Nelson Iain Wallace Christopher H. Eskiw |
| author_sort | Morgan Fleming |
| collection | DOAJ |
| description | Background: Our daily intake of food provides nutrients for the maintenance of health, growth and development. The field of nutrigenomics aims to link dietary intake/nutrients to changes in epigenetic status and gene expression.
Summary: Although the relationship between our diet and our genes in under intense investigation, there is still as significant aspect of our genome that have received little attention with regards to this. In the past 15 years the importance of genome organization has become increasingly evident, with research identifying small scale local changes to large segments of the genome dynamically repositioning within the nucleus in response to/or mediating change in gene expression. The discovery of these dynamic processes and organization maybe as significant as dynamic plate tectonics is to geology, there is little information tying genome organization to specific nutrients or dietary intake.
Key Messages: Here we detail key principles of genome organization and structure, with emphasis on genome folding and organization, and link how these contribute to our future understand of nutrigenomics. |
| first_indexed | 2024-04-13T06:56:14Z |
| format | Article |
| id | doaj.art-b5bba58dd15d4f2cb2c95f4cab433829 |
| institution | Directory Open Access Journal |
| issn | 2504-3161 2504-3188 |
| language | English |
| last_indexed | 2024-04-13T06:56:14Z |
| publishDate | 2022-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Lifestyle Genomics |
| spelling | doaj.art-b5bba58dd15d4f2cb2c95f4cab4338292022-12-22T02:57:14ZengKarger PublishersLifestyle Genomics2504-31612504-31882022-11-0110.1159/000528011528011Genome tectonics: linking dynamic genome organization with cellular nutrientMorgan FlemingFina NelsonIain Wallacehttps://orcid.org/0000-0001-8761-503XChristopher H. Eskiwhttps://orcid.org/0000-0003-3005-941XBackground: Our daily intake of food provides nutrients for the maintenance of health, growth and development. The field of nutrigenomics aims to link dietary intake/nutrients to changes in epigenetic status and gene expression. Summary: Although the relationship between our diet and our genes in under intense investigation, there is still as significant aspect of our genome that have received little attention with regards to this. In the past 15 years the importance of genome organization has become increasingly evident, with research identifying small scale local changes to large segments of the genome dynamically repositioning within the nucleus in response to/or mediating change in gene expression. The discovery of these dynamic processes and organization maybe as significant as dynamic plate tectonics is to geology, there is little information tying genome organization to specific nutrients or dietary intake. Key Messages: Here we detail key principles of genome organization and structure, with emphasis on genome folding and organization, and link how these contribute to our future understand of nutrigenomics.https://www.karger.com/Article/FullText/528011 |
| spellingShingle | Morgan Fleming Fina Nelson Iain Wallace Christopher H. Eskiw Genome tectonics: linking dynamic genome organization with cellular nutrient Lifestyle Genomics |
| title | Genome tectonics: linking dynamic genome organization with cellular nutrient |
| title_full | Genome tectonics: linking dynamic genome organization with cellular nutrient |
| title_fullStr | Genome tectonics: linking dynamic genome organization with cellular nutrient |
| title_full_unstemmed | Genome tectonics: linking dynamic genome organization with cellular nutrient |
| title_short | Genome tectonics: linking dynamic genome organization with cellular nutrient |
| title_sort | genome tectonics linking dynamic genome organization with cellular nutrient |
| url | https://www.karger.com/Article/FullText/528011 |
| work_keys_str_mv | AT morganfleming genometectonicslinkingdynamicgenomeorganizationwithcellularnutrient AT finanelson genometectonicslinkingdynamicgenomeorganizationwithcellularnutrient AT iainwallace genometectonicslinkingdynamicgenomeorganizationwithcellularnutrient AT christopherheskiw genometectonicslinkingdynamicgenomeorganizationwithcellularnutrient |