Compositional and functional variability of the gut microbiome in children with infantile colic
Abstract The inconsolable crying of a child for no apparent reason at an early age is a source of excitement and anxiety for parents. Previous studies have reported that crying may be caused by discomfort associated with the occupation of the intestines of the newborn by microbiota and its vital act...
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| Format: | Article |
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-36641-z |
| _version_ | 1797801459523256320 |
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| author | Samat Kozhakhmetov Zarina Meiirmanova Nurislam Mukhanbetzhanov Zharkyn Jarmukhanov Elizaveta Vinogradova Shamil Mureyev Saniya Kozhakhmetova Marina Morenko Kseniya Shnaider Arailym Duisbayeva Almagul Kushugulova |
| author_facet | Samat Kozhakhmetov Zarina Meiirmanova Nurislam Mukhanbetzhanov Zharkyn Jarmukhanov Elizaveta Vinogradova Shamil Mureyev Saniya Kozhakhmetova Marina Morenko Kseniya Shnaider Arailym Duisbayeva Almagul Kushugulova |
| author_sort | Samat Kozhakhmetov |
| collection | DOAJ |
| description | Abstract The inconsolable crying of a child for no apparent reason at an early age is a source of excitement and anxiety for parents. Previous studies have reported that crying may be caused by discomfort associated with the occupation of the intestines of the newborn by microbiota and its vital activity. We conducted a prospective observational study in which 62 newborns and their mothers were recruited. The study comprised two groups, each consisting of 15 infants with colic and 21 controls. Colic and control groups were vaginally born and exclusively breastfed. Fecal samples from children were collected over time from day 1 to 12 months. Full metagenomic sequencing of fecal samples from children and their mothers was carried out. It was determined that the trajectory of the development of the intestinal microbiome of children with colic was different from the group without colic. In the colic group, a depleted relative abundance of Bifidobacterium and enrichment of Bacteroides Clostridiales was found, while the microbial biodiversity in this group was enriched. Metabolic pathway profiling showed that the non-colic group was enriched by amino acid biosynthetic pathways, while the feces microbiome of the colic group was enriched by glycolysis metabolic pathways that correlated with the Bacteroides taxon. This study shows that infantile colic has a definite relationship with the microbiome structure of infants. |
| first_indexed | 2024-03-13T04:50:47Z |
| format | Article |
| id | doaj.art-b5bc5e52955c423ea9ceae808b8500b0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T04:50:47Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b5bc5e52955c423ea9ceae808b8500b02023-06-18T11:12:30ZengNature PortfolioScientific Reports2045-23222023-06-0113111010.1038/s41598-023-36641-zCompositional and functional variability of the gut microbiome in children with infantile colicSamat Kozhakhmetov0Zarina Meiirmanova1Nurislam Mukhanbetzhanov2Zharkyn Jarmukhanov3Elizaveta Vinogradova4Shamil Mureyev5Saniya Kozhakhmetova6Marina Morenko7Kseniya Shnaider8Arailym Duisbayeva9Almagul Kushugulova10Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev UniversityDepartment of Children’s Diseases with Courses in Allergology, Hematology and Endocrinology, NJSC “Astana Medical University”Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev UniversityLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev UniversityLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev UniversityLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev UniversityNational Center for BiotechnologyDepartment of Children’s Diseases with Courses in Allergology, Hematology and Endocrinology, NJSC “Astana Medical University”Department of Children’s Diseases with Courses in Allergology, Hematology and Endocrinology, NJSC “Astana Medical University”Department of Children’s Diseases with Courses in Allergology, Hematology and Endocrinology, NJSC “Astana Medical University”Laboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev UniversityAbstract The inconsolable crying of a child for no apparent reason at an early age is a source of excitement and anxiety for parents. Previous studies have reported that crying may be caused by discomfort associated with the occupation of the intestines of the newborn by microbiota and its vital activity. We conducted a prospective observational study in which 62 newborns and their mothers were recruited. The study comprised two groups, each consisting of 15 infants with colic and 21 controls. Colic and control groups were vaginally born and exclusively breastfed. Fecal samples from children were collected over time from day 1 to 12 months. Full metagenomic sequencing of fecal samples from children and their mothers was carried out. It was determined that the trajectory of the development of the intestinal microbiome of children with colic was different from the group without colic. In the colic group, a depleted relative abundance of Bifidobacterium and enrichment of Bacteroides Clostridiales was found, while the microbial biodiversity in this group was enriched. Metabolic pathway profiling showed that the non-colic group was enriched by amino acid biosynthetic pathways, while the feces microbiome of the colic group was enriched by glycolysis metabolic pathways that correlated with the Bacteroides taxon. This study shows that infantile colic has a definite relationship with the microbiome structure of infants.https://doi.org/10.1038/s41598-023-36641-z |
| spellingShingle | Samat Kozhakhmetov Zarina Meiirmanova Nurislam Mukhanbetzhanov Zharkyn Jarmukhanov Elizaveta Vinogradova Shamil Mureyev Saniya Kozhakhmetova Marina Morenko Kseniya Shnaider Arailym Duisbayeva Almagul Kushugulova Compositional and functional variability of the gut microbiome in children with infantile colic Scientific Reports |
| title | Compositional and functional variability of the gut microbiome in children with infantile colic |
| title_full | Compositional and functional variability of the gut microbiome in children with infantile colic |
| title_fullStr | Compositional and functional variability of the gut microbiome in children with infantile colic |
| title_full_unstemmed | Compositional and functional variability of the gut microbiome in children with infantile colic |
| title_short | Compositional and functional variability of the gut microbiome in children with infantile colic |
| title_sort | compositional and functional variability of the gut microbiome in children with infantile colic |
| url | https://doi.org/10.1038/s41598-023-36641-z |
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