Simplified and Rapid Determination of Primaquine and 5,6-Orthoquinone Primaquine by UHPLC-MS/MS: Its Application to a Pharmacokinetic Study

Simplified and Rapid Determination of Primaquine and 5,6-Orthoquinone Primaquine by UHPLC-MS/MS: Its Application to a Pharmacokinetic Study

The method for the determination of primaquine (PQ) and 5,6-orthoquinone primaquine (5,6-PQ), the representative marker for PQ active metabolites, via CYP2D6 in human plasma and urine has been validated. All samples were extracted using acetonitrile for protein precipitation and analyzed using the u...

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Bibliographic Details
Main Authors: Waritda Pookmanee, Siriwan Thongthip, Jeeranut Tankanitlert, Mathirut Mungthin, Chonlaphat Sukasem, Supeecha Wittayalertpanya
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
primaquine
5,6-orthoquinone-primaquine
plasma
urine
Online Access:https://www.mdpi.com/1420-3049/26/14/4357

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