Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study
Abstract Background To explore the associations between the Chinese famine exposure in early life and the dyslipidemia in adulthood. Methods We selected 2752 participants from the baseline survey of China Health and Retirement Longitudinal Study (CHARLS) 2011–2012 to evaluate the associations of ear...
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BMC
2017-06-01
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| Series: | BMC Public Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12889-017-4421-6 |
| _version_ | 1811203347853606912 |
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| author | Zhenghe Wang Changwei Li Zhongping Yang Jun Ma Zhiyong Zou |
| author_facet | Zhenghe Wang Changwei Li Zhongping Yang Jun Ma Zhiyong Zou |
| author_sort | Zhenghe Wang |
| collection | DOAJ |
| description | Abstract Background To explore the associations between the Chinese famine exposure in early life and the dyslipidemia in adulthood. Methods We selected 2752 participants from the baseline survey of China Health and Retirement Longitudinal Study (CHARLS) 2011–2012 to evaluate the associations of early life the Chinese famine exposure with risk of dyslipidemia in adulthood. Dyslipidemia was defined as TC (Total Cholesterol): HDL-C (High-Density Lipoprotein Cholesterol) ratio ≥ 5.0 or use cholesterol lowering drugs. Famine exposure cohorts were categorized by birthdates of participants. Binary logistics regression model was used to examine the associations of early-life famine exposure with the risk of dyslipidemia. Results The dyslipidemia prevalence of the non-exposed cohort, fetal stage-, infant stage-, and preschool stage-exposed cohorts in adulthood was 15.7%, 23.1%, 22.0%, and 18.6%, respectively. Early-life exposure to the Chinese famine significantly increased LDL cholesterol concentrations in adulthood after adjusted for age. The risks of dyslipidemia in fetal (OR = 1.58; 95% CI: 1.23–2.03; P < 0.001) and infant (OR = 1.52; 95% CI: 1.15–2.00; P = 0.003) stage-exposed cohorts were significantly higher than the non-exposed cohort after adjusted for gender and current family economic status. Following gender stratification, we found that fetal (OR = 1.80; 95% CI: 1.26–2.57; P = 0.001), infant (OR = 1.75; 95% CI: 1.17–2.62; P = 0.006), and preschool (OR = 1.63; 95% CI: 1.10–2.42; P = 0.015) -stage exposure to severe famine aggravated the risk of dyslipidemia in female adults. However, the similar association was not observed for male adults. Conclusions Early-life exposure to severe Chinese famine could link with the higher dyslipidemia risk in female adulthood, but not in male adulthood. This gender-specific effect might be associated with the hypothesis that parents in China prefer boys to girls traditionally or survivors’ bias. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-12T02:54:24Z |
| publishDate | 2017-06-01 |
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| series | BMC Public Health |
| spelling | doaj.art-b5bc923de4fb480cb6b428733dc7e5b82022-12-22T03:50:52ZengBMCBMC Public Health1471-24582017-06-011711910.1186/s12889-017-4421-6Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal studyZhenghe Wang0Changwei Li1Zhongping Yang2Jun Ma3Zhiyong Zou4Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science CenterDepartment of Epidemiology, Tulane University School of Public Health and Tropical MedicineInstitute of Child and Adolescent Health, School of Public Health, Peking University Health Science CenterInstitute of Child and Adolescent Health, School of Public Health, Peking University Health Science CenterInstitute of Child and Adolescent Health, School of Public Health, Peking University Health Science CenterAbstract Background To explore the associations between the Chinese famine exposure in early life and the dyslipidemia in adulthood. Methods We selected 2752 participants from the baseline survey of China Health and Retirement Longitudinal Study (CHARLS) 2011–2012 to evaluate the associations of early life the Chinese famine exposure with risk of dyslipidemia in adulthood. Dyslipidemia was defined as TC (Total Cholesterol): HDL-C (High-Density Lipoprotein Cholesterol) ratio ≥ 5.0 or use cholesterol lowering drugs. Famine exposure cohorts were categorized by birthdates of participants. Binary logistics regression model was used to examine the associations of early-life famine exposure with the risk of dyslipidemia. Results The dyslipidemia prevalence of the non-exposed cohort, fetal stage-, infant stage-, and preschool stage-exposed cohorts in adulthood was 15.7%, 23.1%, 22.0%, and 18.6%, respectively. Early-life exposure to the Chinese famine significantly increased LDL cholesterol concentrations in adulthood after adjusted for age. The risks of dyslipidemia in fetal (OR = 1.58; 95% CI: 1.23–2.03; P < 0.001) and infant (OR = 1.52; 95% CI: 1.15–2.00; P = 0.003) stage-exposed cohorts were significantly higher than the non-exposed cohort after adjusted for gender and current family economic status. Following gender stratification, we found that fetal (OR = 1.80; 95% CI: 1.26–2.57; P = 0.001), infant (OR = 1.75; 95% CI: 1.17–2.62; P = 0.006), and preschool (OR = 1.63; 95% CI: 1.10–2.42; P = 0.015) -stage exposure to severe famine aggravated the risk of dyslipidemia in female adults. However, the similar association was not observed for male adults. Conclusions Early-life exposure to severe Chinese famine could link with the higher dyslipidemia risk in female adulthood, but not in male adulthood. This gender-specific effect might be associated with the hypothesis that parents in China prefer boys to girls traditionally or survivors’ bias.http://link.springer.com/article/10.1186/s12889-017-4421-6Chinese famineFetal malnutritionDyslipidemiaGender difference |
| spellingShingle | Zhenghe Wang Changwei Li Zhongping Yang Jun Ma Zhiyong Zou Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study BMC Public Health Chinese famine Fetal malnutrition Dyslipidemia Gender difference |
| title | Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study |
| title_full | Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study |
| title_fullStr | Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study |
| title_full_unstemmed | Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study |
| title_short | Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study |
| title_sort | fetal and infant exposure to severe chinese famine increases the risk of adult dyslipidemia results from the china health and retirement longitudinal study |
| topic | Chinese famine Fetal malnutrition Dyslipidemia Gender difference |
| url | http://link.springer.com/article/10.1186/s12889-017-4421-6 |
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