Macrophage metabolism in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) and its inflammatory and often progressive subtype nonalcoholic steatohepatitis (NASH), have emerged as significant contributors to hepatic morbidity worldwide. The pathophysiology of NAFLD/NASH is multifaceted, variable, and remains incompletely understood....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1257596/full |
| _version_ | 1827800030517395456 |
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| author | Wenhui Zhang Ren Lang |
| author_facet | Wenhui Zhang Ren Lang |
| author_sort | Wenhui Zhang |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) and its inflammatory and often progressive subtype nonalcoholic steatohepatitis (NASH), have emerged as significant contributors to hepatic morbidity worldwide. The pathophysiology of NAFLD/NASH is multifaceted, variable, and remains incompletely understood. The pivotal role of liver-resident and recruited macrophages in the pathogenesis of NAFLD and NASH is widely acknowledged as a crucial factor in innate immunity. The remarkable plasticity of macrophages enables them to assume diverse activation and polarization states, dictated by their immunometabolism microenvironment and functional requirements. Recent studies in the field of immunometabolism have elucidated that alterations in the metabolic profile of macrophages can profoundly influence their activation state and functionality, thereby influencing various pathological processes. This review primarily focuses on elucidating the polarization and activation states of macrophages, highlighting the correlation between their metabolic characteristics and the transition from pro-inflammatory to anti-inflammatory phenotypes. Additionally, we explore the potential of targeting macrophage metabolism as a promising therapeutic approach for the management of NAFLD/NASH. |
| first_indexed | 2024-03-11T20:00:42Z |
| format | Article |
| id | doaj.art-b5bdfd9dba2a4b5da316771cf05abf11 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T20:00:42Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b5bdfd9dba2a4b5da316771cf05abf112023-10-04T08:50:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12575961257596Macrophage metabolism in nonalcoholic fatty liver diseaseWenhui ZhangRen LangNonalcoholic fatty liver disease (NAFLD) and its inflammatory and often progressive subtype nonalcoholic steatohepatitis (NASH), have emerged as significant contributors to hepatic morbidity worldwide. The pathophysiology of NAFLD/NASH is multifaceted, variable, and remains incompletely understood. The pivotal role of liver-resident and recruited macrophages in the pathogenesis of NAFLD and NASH is widely acknowledged as a crucial factor in innate immunity. The remarkable plasticity of macrophages enables them to assume diverse activation and polarization states, dictated by their immunometabolism microenvironment and functional requirements. Recent studies in the field of immunometabolism have elucidated that alterations in the metabolic profile of macrophages can profoundly influence their activation state and functionality, thereby influencing various pathological processes. This review primarily focuses on elucidating the polarization and activation states of macrophages, highlighting the correlation between their metabolic characteristics and the transition from pro-inflammatory to anti-inflammatory phenotypes. Additionally, we explore the potential of targeting macrophage metabolism as a promising therapeutic approach for the management of NAFLD/NASH.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1257596/fullnonalcoholic fatty liver diseasemacrophageimmunometabolismpolarizationactivationtherapeutic target |
| spellingShingle | Wenhui Zhang Ren Lang Macrophage metabolism in nonalcoholic fatty liver disease Frontiers in Immunology nonalcoholic fatty liver disease macrophage immunometabolism polarization activation therapeutic target |
| title | Macrophage metabolism in nonalcoholic fatty liver disease |
| title_full | Macrophage metabolism in nonalcoholic fatty liver disease |
| title_fullStr | Macrophage metabolism in nonalcoholic fatty liver disease |
| title_full_unstemmed | Macrophage metabolism in nonalcoholic fatty liver disease |
| title_short | Macrophage metabolism in nonalcoholic fatty liver disease |
| title_sort | macrophage metabolism in nonalcoholic fatty liver disease |
| topic | nonalcoholic fatty liver disease macrophage immunometabolism polarization activation therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1257596/full |
| work_keys_str_mv | AT wenhuizhang macrophagemetabolisminnonalcoholicfattyliverdisease AT renlang macrophagemetabolisminnonalcoholicfattyliverdisease |