A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats

A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats

Neuroaxonal dystrophy (NAD) is a neurodegenerative disease characterized by spheroid (swollen axon) formation in the nervous system. In the present study, we focused on a newly established autosomal recessive mutant strain of F344-kk/kk rats with hind limb gait abnormalities and ataxia from a young...

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Bibliographic Details
Main Authors: Miyuu Tanaka, Ryoko Fujikawa, Takahiro Sekiguchi, Jason Hernandez, Oleta T. Johnson, Daisuke Tanaka, Kenta Kumafuji, Tadao Serikawa, Hieu Hoang Trung, Kosuke Hattori, Tomoji Mashimo, Mitsuru Kuwamura, Jason E. Gestwicki, Takashi Kuramoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Neuroscience
Subjects:
animal model
axon
Hspa8
neuroaxonal dystrophy
rat
spheroid
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1263724/full

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