Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study
Abstract Background Vegetables is the main sources of dietary nitrate. Studies suggested the potential link between nitrate content of vegetables and reduce the risk of chronic diseases. We aimed to assess the association between nitrate-containing vegetables (NCVs) with odds of nonalcoholic fatty l...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-01-01
|
| Series: | Nutrition Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12937-023-00834-z |
| _version_ | 1797952645856493568 |
|---|---|
| author | Parvin Mirmiran Farshad Teymoori Hossein Farhadnejad Ebrahim Mokhtari Ammar Salehi-Sahlabadi |
| author_facet | Parvin Mirmiran Farshad Teymoori Hossein Farhadnejad Ebrahim Mokhtari Ammar Salehi-Sahlabadi |
| author_sort | Parvin Mirmiran |
| collection | DOAJ |
| description | Abstract Background Vegetables is the main sources of dietary nitrate. Studies suggested the potential link between nitrate content of vegetables and reduce the risk of chronic diseases. We aimed to assess the association between nitrate-containing vegetables (NCVs) with odds of nonalcoholic fatty liver diseases (NAFLD) in Iranian adults. Method This case-control study was performed on a total of 225 newly diagnosed NAFLD cases and 450 controls aged 20–60 years. Individuals’ dietary intakes were determined using a valid and reliable food frequency questionnaire. Results The mean ± SD age and BMI of participants were 38.1 ± 8.8 years and 26.8 ± 4.3 kg/m2, respectively. In the fully adjusted model, the odds of NAFLD were decreased across tertiles of total NCVs [(adjusted OR: 0.20, 95%CI: 0.10–0.40), (Ptrend < 0.001)] and low-nitrate vegetables [(adjusted OR: 0.22, 95%CI: 0.11–0.48), (Ptrend < 0.001)]. Our results showed that each one SD increments in nitrate content of vegetables (adjusted OR: 0.73, 95%CI: 0.55–0.97) and nitrate content of fruits (adjusted OR: 0.59, 95%CI: 0.36–0.97) was associated with reduced odds of NAFLD (P < 0.05). However, there was a positive association between each one SD increments in nitrate content of dairy products and meats and processed meats with odds of NAFLD (adjusted OR: 1.34, 95%CI: 1.03–1.74), (P < 0.05). Conclusion Our finding suggested that a higher intake of vegetable nitrate may be related to a decrease the odds of NAFLD. |
| first_indexed | 2024-04-10T22:50:45Z |
| format | Article |
| id | doaj.art-b5bfad51d2a8482998b635b61eb87bbe |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-04-10T22:50:45Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-b5bfad51d2a8482998b635b61eb87bbe2023-01-15T12:05:02ZengBMCNutrition Journal1475-28912023-01-012211810.1186/s12937-023-00834-zNitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control studyParvin Mirmiran0Farshad Teymoori1Hossein Farhadnejad2Ebrahim Mokhtari3Ammar Salehi-Sahlabadi4Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesNutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesNutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesNutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Facualty of Nutrition and Food Technology, National Nutrition and Food Technology, Shahid Beheshti University of Medical SciencesAbstract Background Vegetables is the main sources of dietary nitrate. Studies suggested the potential link between nitrate content of vegetables and reduce the risk of chronic diseases. We aimed to assess the association between nitrate-containing vegetables (NCVs) with odds of nonalcoholic fatty liver diseases (NAFLD) in Iranian adults. Method This case-control study was performed on a total of 225 newly diagnosed NAFLD cases and 450 controls aged 20–60 years. Individuals’ dietary intakes were determined using a valid and reliable food frequency questionnaire. Results The mean ± SD age and BMI of participants were 38.1 ± 8.8 years and 26.8 ± 4.3 kg/m2, respectively. In the fully adjusted model, the odds of NAFLD were decreased across tertiles of total NCVs [(adjusted OR: 0.20, 95%CI: 0.10–0.40), (Ptrend < 0.001)] and low-nitrate vegetables [(adjusted OR: 0.22, 95%CI: 0.11–0.48), (Ptrend < 0.001)]. Our results showed that each one SD increments in nitrate content of vegetables (adjusted OR: 0.73, 95%CI: 0.55–0.97) and nitrate content of fruits (adjusted OR: 0.59, 95%CI: 0.36–0.97) was associated with reduced odds of NAFLD (P < 0.05). However, there was a positive association between each one SD increments in nitrate content of dairy products and meats and processed meats with odds of NAFLD (adjusted OR: 1.34, 95%CI: 1.03–1.74), (P < 0.05). Conclusion Our finding suggested that a higher intake of vegetable nitrate may be related to a decrease the odds of NAFLD.https://doi.org/10.1186/s12937-023-00834-zNitrateNitrate-containing vegetablesNonalcoholic fatty liver diseasesNAFLD |
| spellingShingle | Parvin Mirmiran Farshad Teymoori Hossein Farhadnejad Ebrahim Mokhtari Ammar Salehi-Sahlabadi Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study Nutrition Journal Nitrate Nitrate-containing vegetables Nonalcoholic fatty liver diseases NAFLD |
| title | Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study |
| title_full | Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study |
| title_fullStr | Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study |
| title_full_unstemmed | Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study |
| title_short | Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study |
| title_sort | nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease a case control study |
| topic | Nitrate Nitrate-containing vegetables Nonalcoholic fatty liver diseases NAFLD |
| url | https://doi.org/10.1186/s12937-023-00834-z |
| work_keys_str_mv | AT parvinmirmiran nitratecontainingvegetablesanddietarynitrateandnonalcoholicfattyliverdiseaseacasecontrolstudy AT farshadteymoori nitratecontainingvegetablesanddietarynitrateandnonalcoholicfattyliverdiseaseacasecontrolstudy AT hosseinfarhadnejad nitratecontainingvegetablesanddietarynitrateandnonalcoholicfattyliverdiseaseacasecontrolstudy AT ebrahimmokhtari nitratecontainingvegetablesanddietarynitrateandnonalcoholicfattyliverdiseaseacasecontrolstudy AT ammarsalehisahlabadi nitratecontainingvegetablesanddietarynitrateandnonalcoholicfattyliverdiseaseacasecontrolstudy |