The Incidence and Risk Factors of Acute Kidney Injury After Left Ventricular Assist Device Implantation
Objective:Left ventricular assist device surgery (LVAD) associated acute kidney injury (AKI) is a severe complication of cardiac surgery with 15-45% incidence. The study evaluated AKI in the early postoperative period after LVAD surgery using the Kidney Disease: Improving Global Outcomes (KDIGO) cri...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-09-01
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| Series: | Türk Yoğun Bakim Derneği Dergisi |
| Subjects: | |
| Online Access: |
http://www.turkishjic.org/archives/archive-detail/article-preview/the-ncidence-and-risk-factors-of-acute-kidney-njur/57796
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| _version_ | 1797673396196081664 |
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| author | Funda Atar Helin Şahintürk Aycan Özdemirkan Özgür Ersoy Pınar Zeyneloğlu |
| author_facet | Funda Atar Helin Şahintürk Aycan Özdemirkan Özgür Ersoy Pınar Zeyneloğlu |
| author_sort | Funda Atar |
| collection | DOAJ |
| description | Objective:Left ventricular assist device surgery (LVAD) associated acute kidney injury (AKI) is a severe complication of cardiac surgery with 15-45% incidence. The study evaluated AKI in the early postoperative period after LVAD surgery using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria and compare patients with and without AKI to determine the incidence, risk factors, and clinical outcomes.Materials and Methods:In this retrospective cohort study, the medical records of all patients aged between 18 and 75 years who underwent LVAD implantation from January 2011 to December 2016 were reviewed. Patients were divided into two groups based on the development of AKI to analyze demographic features and perioperative variables. AKI was defined according to the KDIGO criteria.Results:Out of 57 patients, 10 (18%) were female, and the cohort’s mean age was 44.6±16.1 years. Thirty-six patients (63%) developed AKI following LVAD implantation. Logistic regression analysis revealed the duration of cardiopulmonary bypass (CPB), mean arterial pressure, and cumulative fluid balance on the first postoperative day as independent risk factors for AKI [odds ratio (OR): 1.013, confidence interval (CI) 95% 1.000-1.025, p=0.05; OR: 0.929, CI 95% 0.873-0.989, p=0.02; OR: 1.001, CI 95% 1.000-1.001, p=0.04 respectively]. Hospital mortality (58% vs. 24%, p=0.01) and 30-day mortality (39% vs. 5%, p=0.01) were significantly higher in patients who had AKI.Conclusion:Risk factors for the occurrence of AKI include a longer duration of CPB, lower mean arterial pressures, and higher cumulative fluid balance on the first postoperative day. Therefore, AKI is one of the most important causes of morbidity and mortality after LVAD. |
| first_indexed | 2024-03-11T21:44:53Z |
| format | Article |
| id | doaj.art-b5c08599df254a5bbd4133cfcb6bf99d |
| institution | Directory Open Access Journal |
| issn | 2146-6416 2147-267X |
| language | English |
| last_indexed | 2024-03-11T21:44:53Z |
| publishDate | 2023-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Yoğun Bakim Derneği Dergisi |
| spelling | doaj.art-b5c08599df254a5bbd4133cfcb6bf99d2023-09-26T10:48:07ZengGalenos YayineviTürk Yoğun Bakim Derneği Dergisi2146-64162147-267X2023-09-0121320221110.4274/tybd.galenos.2022.5770413049054The Incidence and Risk Factors of Acute Kidney Injury After Left Ventricular Assist Device ImplantationFunda Atar0Helin Şahintürk1Aycan Özdemirkan2Özgür Ersoy3Pınar Zeyneloğlu4 University of Health Sciences Turkey, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Clinic of Anesthesiology and Reanimation, Ankara, Turkey Başkent University Faculty of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey Gazi University Faculty of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey University of Health Sciences Turkey, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Clinic of Cardiovascular Surgery, Ankara, Turkey Başkent University Faculty of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey Objective:Left ventricular assist device surgery (LVAD) associated acute kidney injury (AKI) is a severe complication of cardiac surgery with 15-45% incidence. The study evaluated AKI in the early postoperative period after LVAD surgery using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria and compare patients with and without AKI to determine the incidence, risk factors, and clinical outcomes.Materials and Methods:In this retrospective cohort study, the medical records of all patients aged between 18 and 75 years who underwent LVAD implantation from January 2011 to December 2016 were reviewed. Patients were divided into two groups based on the development of AKI to analyze demographic features and perioperative variables. AKI was defined according to the KDIGO criteria.Results:Out of 57 patients, 10 (18%) were female, and the cohort’s mean age was 44.6±16.1 years. Thirty-six patients (63%) developed AKI following LVAD implantation. Logistic regression analysis revealed the duration of cardiopulmonary bypass (CPB), mean arterial pressure, and cumulative fluid balance on the first postoperative day as independent risk factors for AKI [odds ratio (OR): 1.013, confidence interval (CI) 95% 1.000-1.025, p=0.05; OR: 0.929, CI 95% 0.873-0.989, p=0.02; OR: 1.001, CI 95% 1.000-1.001, p=0.04 respectively]. Hospital mortality (58% vs. 24%, p=0.01) and 30-day mortality (39% vs. 5%, p=0.01) were significantly higher in patients who had AKI.Conclusion:Risk factors for the occurrence of AKI include a longer duration of CPB, lower mean arterial pressures, and higher cumulative fluid balance on the first postoperative day. Therefore, AKI is one of the most important causes of morbidity and mortality after LVAD. http://www.turkishjic.org/archives/archive-detail/article-preview/the-ncidence-and-risk-factors-of-acute-kidney-njur/57796 acute kidney injuryintensive careleft ventricle assist device |
| spellingShingle | Funda Atar Helin Şahintürk Aycan Özdemirkan Özgür Ersoy Pınar Zeyneloğlu The Incidence and Risk Factors of Acute Kidney Injury After Left Ventricular Assist Device Implantation Türk Yoğun Bakim Derneği Dergisi acute kidney injury intensive care left ventricle assist device |
| title | The Incidence and Risk Factors of Acute Kidney Injury After Left Ventricular Assist Device Implantation |
| title_full | The Incidence and Risk Factors of Acute Kidney Injury After Left Ventricular Assist Device Implantation |
| title_fullStr | The Incidence and Risk Factors of Acute Kidney Injury After Left Ventricular Assist Device Implantation |
| title_full_unstemmed | The Incidence and Risk Factors of Acute Kidney Injury After Left Ventricular Assist Device Implantation |
| title_short | The Incidence and Risk Factors of Acute Kidney Injury After Left Ventricular Assist Device Implantation |
| title_sort | incidence and risk factors of acute kidney injury after left ventricular assist device implantation |
| topic | acute kidney injury intensive care left ventricle assist device |
| url |
http://www.turkishjic.org/archives/archive-detail/article-preview/the-ncidence-and-risk-factors-of-acute-kidney-njur/57796
|
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