The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer Treatment
Lonidamine (LND) has the ability to resist spermatogenesis and was first used as an anti-spermatogenic agent. Later, it was found that LND has a degree of anticancer activity. Currently, LND is known to target energy metabolism, mainly involving the inhibition of monocarboxylate transporter (MCT), m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/11/3332 |
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| author | Yaxin Huang Guohui Sun Xiaodong Sun Feifan Li Lijiao Zhao Rugang Zhong Yongzhen Peng |
| author_facet | Yaxin Huang Guohui Sun Xiaodong Sun Feifan Li Lijiao Zhao Rugang Zhong Yongzhen Peng |
| author_sort | Yaxin Huang |
| collection | DOAJ |
| description | Lonidamine (LND) has the ability to resist spermatogenesis and was first used as an anti-spermatogenic agent. Later, it was found that LND has a degree of anticancer activity. Currently, LND is known to target energy metabolism, mainly involving the inhibition of monocarboxylate transporter (MCT), mitochondrial pyruvate carrier (MPC), respiratory chain complex I/II, mitochondrial permeability transition (PT) pore, and hexokinase II (HK-II). However, phase II clinical studies showed that LND alone had a weak therapeutic effect, and the effect was short and reversible. Interestingly, LND does not have the common side effects of traditional chemotherapeutic drugs, such as alopecia and myelosuppression. In addition, LND has selective activity toward various tumors, and its toxic and side effects do not overlap when combined with other chemotherapeutic drugs. Therefore, LND is commonly used as a chemosensitizer to enhance the antitumor effects of chemotherapeutic drugs based on its disruption of energy metabolism relating to chemo- or radioresistance. In this review, we summarized the combination treatments of LND with several typical chemotherapeutic drugs and several common physical therapies, such as radiotherapy (RT), hyperthermia (HT), and photodynamic therapy (PDT), and discussed the underlying mechanisms of action. Meanwhile, the development of novel formulations of LND in recent years and the research progress of LND derivative adjudin (ADD) as an anticancer drug were also discussed. |
| first_indexed | 2024-03-10T14:56:07Z |
| format | Article |
| id | doaj.art-b5c40312e44e419686f6a6f210cf459d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T14:56:07Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b5c40312e44e419686f6a6f210cf459d2023-11-20T20:34:04ZengMDPI AGCancers2072-66942020-11-011211333210.3390/cancers12113332The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer TreatmentYaxin Huang0Guohui Sun1Xiaodong Sun2Feifan Li3Lijiao Zhao4Rugang Zhong5Yongzhen Peng6Beijing Key Laboratory of Environment and Viral Oncology, College of Life Science and Chemistry, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, ChinaBeijing Key Laboratory of Environment and Viral Oncology, College of Life Science and Chemistry, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, ChinaBeijing Key Laboratory of Environment and Viral Oncology, College of Life Science and Chemistry, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, ChinaBeijing Key Laboratory of Environment and Viral Oncology, College of Life Science and Chemistry, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, ChinaBeijing Key Laboratory of Environment and Viral Oncology, College of Life Science and Chemistry, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, ChinaBeijing Key Laboratory of Environment and Viral Oncology, College of Life Science and Chemistry, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, ChinaNational Engineering Laboratory for Advanced Municipal Wastewater Treatment & Reuse Technology, Engineering Research Center of Beijing, Beijing University of Technology, Beijing 100124, ChinaLonidamine (LND) has the ability to resist spermatogenesis and was first used as an anti-spermatogenic agent. Later, it was found that LND has a degree of anticancer activity. Currently, LND is known to target energy metabolism, mainly involving the inhibition of monocarboxylate transporter (MCT), mitochondrial pyruvate carrier (MPC), respiratory chain complex I/II, mitochondrial permeability transition (PT) pore, and hexokinase II (HK-II). However, phase II clinical studies showed that LND alone had a weak therapeutic effect, and the effect was short and reversible. Interestingly, LND does not have the common side effects of traditional chemotherapeutic drugs, such as alopecia and myelosuppression. In addition, LND has selective activity toward various tumors, and its toxic and side effects do not overlap when combined with other chemotherapeutic drugs. Therefore, LND is commonly used as a chemosensitizer to enhance the antitumor effects of chemotherapeutic drugs based on its disruption of energy metabolism relating to chemo- or radioresistance. In this review, we summarized the combination treatments of LND with several typical chemotherapeutic drugs and several common physical therapies, such as radiotherapy (RT), hyperthermia (HT), and photodynamic therapy (PDT), and discussed the underlying mechanisms of action. Meanwhile, the development of novel formulations of LND in recent years and the research progress of LND derivative adjudin (ADD) as an anticancer drug were also discussed.https://www.mdpi.com/2072-6694/12/11/3332Lonidamineenergy metabolismcombinationresistancechemotherapyphysical therapy |
| spellingShingle | Yaxin Huang Guohui Sun Xiaodong Sun Feifan Li Lijiao Zhao Rugang Zhong Yongzhen Peng The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer Treatment Cancers Lonidamine energy metabolism combination resistance chemotherapy physical therapy |
| title | The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer Treatment |
| title_full | The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer Treatment |
| title_fullStr | The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer Treatment |
| title_full_unstemmed | The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer Treatment |
| title_short | The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer Treatment |
| title_sort | potential of lonidamine in combination with chemotherapy and physical therapy in cancer treatment |
| topic | Lonidamine energy metabolism combination resistance chemotherapy physical therapy |
| url | https://www.mdpi.com/2072-6694/12/11/3332 |
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