The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and Tumorigenesis
Post-transcriptional control of gene expression is one important mechanism that enables stringent and rapid modulation of cytokine, chemokines or growth factors expression, all relevant for immune or tumor cell function and communication. The RNA-binding protein KH-type splicing regulatory protein (...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/9/1482 |
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| author | Kim-Alicia Palzer Vanessa Bolduan Rudolf Käfer Hartmut Kleinert Matthias Bros Andrea Pautz |
| author_facet | Kim-Alicia Palzer Vanessa Bolduan Rudolf Käfer Hartmut Kleinert Matthias Bros Andrea Pautz |
| author_sort | Kim-Alicia Palzer |
| collection | DOAJ |
| description | Post-transcriptional control of gene expression is one important mechanism that enables stringent and rapid modulation of cytokine, chemokines or growth factors expression, all relevant for immune or tumor cell function and communication. The RNA-binding protein KH-type splicing regulatory protein (KSRP) controls the mRNA stability of according genes by initiation of mRNA decay and inhibition of translation, and by enhancing the maturation of microRNAs. Therefore, KSRP plays a pivotal role in immune cell function and tumor progression. In this review, we summarize the current knowledge about KSRP with regard to the regulation of immunologically relevant targets, and the functional role of KSRP on immune responses and tumorigenesis. KSRP is involved in the control of myeloid hematopoiesis. Further, KSRP-mediated mRNA decay of pro-inflammatory factors is necessary to keep immune homeostasis. In case of infection, functional impairment of KSRP is important for the induction of robust immune responses. In this regard, KSRP seems to primarily dampen T helper cell 2 immune responses. In cancer, KSRP has often been associated with tumor growth and metastasis. In summary, aside of initiation of mRNA decay, the KSRP-mediated regulation of microRNA maturation seems to be especially important for its diverse biological functions, which warrants further in-depth examination. |
| first_indexed | 2024-03-10T04:16:19Z |
| format | Article |
| id | doaj.art-b5c482d83c4d4f1498260adc6e97c547 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:16:19Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b5c482d83c4d4f1498260adc6e97c5472023-11-23T07:59:50ZengMDPI AGCells2073-44092022-04-01119148210.3390/cells11091482The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and TumorigenesisKim-Alicia Palzer0Vanessa Bolduan1Rudolf Käfer2Hartmut Kleinert3Matthias Bros4Andrea Pautz5Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, GermanyDepartment of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, GermanyDepartment of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, GermanyDepartment of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, GermanyDepartment of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, GermanyDepartment of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, GermanyPost-transcriptional control of gene expression is one important mechanism that enables stringent and rapid modulation of cytokine, chemokines or growth factors expression, all relevant for immune or tumor cell function and communication. The RNA-binding protein KH-type splicing regulatory protein (KSRP) controls the mRNA stability of according genes by initiation of mRNA decay and inhibition of translation, and by enhancing the maturation of microRNAs. Therefore, KSRP plays a pivotal role in immune cell function and tumor progression. In this review, we summarize the current knowledge about KSRP with regard to the regulation of immunologically relevant targets, and the functional role of KSRP on immune responses and tumorigenesis. KSRP is involved in the control of myeloid hematopoiesis. Further, KSRP-mediated mRNA decay of pro-inflammatory factors is necessary to keep immune homeostasis. In case of infection, functional impairment of KSRP is important for the induction of robust immune responses. In this regard, KSRP seems to primarily dampen T helper cell 2 immune responses. In cancer, KSRP has often been associated with tumor growth and metastasis. In summary, aside of initiation of mRNA decay, the KSRP-mediated regulation of microRNA maturation seems to be especially important for its diverse biological functions, which warrants further in-depth examination.https://www.mdpi.com/2073-4409/11/9/1482KH-type splicing regulatory proteinpost-transcriptional gene regulationmRNA decaymicro RNAcytokineantiviral response |
| spellingShingle | Kim-Alicia Palzer Vanessa Bolduan Rudolf Käfer Hartmut Kleinert Matthias Bros Andrea Pautz The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and Tumorigenesis Cells KH-type splicing regulatory protein post-transcriptional gene regulation mRNA decay micro RNA cytokine antiviral response |
| title | The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and Tumorigenesis |
| title_full | The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and Tumorigenesis |
| title_fullStr | The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and Tumorigenesis |
| title_full_unstemmed | The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and Tumorigenesis |
| title_short | The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and Tumorigenesis |
| title_sort | role of kh type splicing regulatory protein ksrp for immune functions and tumorigenesis |
| topic | KH-type splicing regulatory protein post-transcriptional gene regulation mRNA decay micro RNA cytokine antiviral response |
| url | https://www.mdpi.com/2073-4409/11/9/1482 |
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