Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring
Abstract The probiotic bacterium Lactobacillus plantarum is often reckoned as a ‘generalist’ for its ability to adapt and survive in diverse ecological niches. The genomic signatures of L. plantarum have shown its intricate evolutionary ancestry and dynamic lifestyles. Here, we report on a unique ge...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-022-00302-2 |
| _version_ | 1818203067894464512 |
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| author | Satish Kumar Rajasekharan Moshe Shemesh |
| author_facet | Satish Kumar Rajasekharan Moshe Shemesh |
| author_sort | Satish Kumar Rajasekharan |
| collection | DOAJ |
| description | Abstract The probiotic bacterium Lactobacillus plantarum is often reckoned as a ‘generalist’ for its ability to adapt and survive in diverse ecological niches. The genomic signatures of L. plantarum have shown its intricate evolutionary ancestry and dynamic lifestyles. Here, we report on a unique geometrical arrangement of the multicellular population of L. plantarum cells. Prominently, a phenomenon of the cone-shaped colony formation and V-shaped cell chaining are discovered in response to the acidic-pH environment. Moreover, subsequent cold stress response triggers an unusual cellular arrangement of consolidated bundles, which appeared to be independently governed by a small heat shock protein (HSP 1). We further report that the V-shaped L. plantarum chaining demonstrates potent antagonistic activity against Candida albicans, a pathogenic yeast, both in vitro and in a Caenorhabditis elegans co-infection model. Finally, we deduce that the multifaceted traits manifested by this probiotic bacterium is an outcome of its dynamic flexibility and cellular heterogeneity. |
| first_indexed | 2024-12-12T03:19:27Z |
| format | Article |
| id | doaj.art-b5c83c7756c34bd7a5be4e976c5b5bc6 |
| institution | Directory Open Access Journal |
| issn | 2055-5008 |
| language | English |
| last_indexed | 2024-12-12T03:19:27Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj.art-b5c83c7756c34bd7a5be4e976c5b5bc62022-12-22T00:40:11ZengNature Portfolionpj Biofilms and Microbiomes2055-50082022-05-018111010.1038/s41522-022-00302-2Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuringSatish Kumar Rajasekharan0Moshe Shemesh1Department of Food Science, Institute of Postharvest Technology and Food Sciences, Agricultural Research Organization (ARO), The Volcani InstituteDepartment of Food Science, Institute of Postharvest Technology and Food Sciences, Agricultural Research Organization (ARO), The Volcani InstituteAbstract The probiotic bacterium Lactobacillus plantarum is often reckoned as a ‘generalist’ for its ability to adapt and survive in diverse ecological niches. The genomic signatures of L. plantarum have shown its intricate evolutionary ancestry and dynamic lifestyles. Here, we report on a unique geometrical arrangement of the multicellular population of L. plantarum cells. Prominently, a phenomenon of the cone-shaped colony formation and V-shaped cell chaining are discovered in response to the acidic-pH environment. Moreover, subsequent cold stress response triggers an unusual cellular arrangement of consolidated bundles, which appeared to be independently governed by a small heat shock protein (HSP 1). We further report that the V-shaped L. plantarum chaining demonstrates potent antagonistic activity against Candida albicans, a pathogenic yeast, both in vitro and in a Caenorhabditis elegans co-infection model. Finally, we deduce that the multifaceted traits manifested by this probiotic bacterium is an outcome of its dynamic flexibility and cellular heterogeneity.https://doi.org/10.1038/s41522-022-00302-2 |
| spellingShingle | Satish Kumar Rajasekharan Moshe Shemesh Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring npj Biofilms and Microbiomes |
| title | Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring |
| title_full | Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring |
| title_fullStr | Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring |
| title_full_unstemmed | Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring |
| title_short | Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring |
| title_sort | spatiotemporal bio shielding of bacteria through consolidated geometrical structuring |
| url | https://doi.org/10.1038/s41522-022-00302-2 |
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