Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women
BackgroundOsteoporosis is a skeletal disease characterized by reduced bone mineral density (BMD), which increases the risk of falls and fractures and reduces mobility. Some nutrients have a well-established role in maintaining bone health and preventing osteoporosis, while selenium (Se) has aroused...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.997414/full |
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| author | Patricia Paula da Fonseca Grili Camila Vilarinho Vidigal Geise Ferreira da Cruz Ben Hur Albergaria José Luiz Marques-Rocha José Luiz Marques-Rocha Taísa Sabrina Silva Pereira Valdete Regina Guandalini Valdete Regina Guandalini |
| author_facet | Patricia Paula da Fonseca Grili Camila Vilarinho Vidigal Geise Ferreira da Cruz Ben Hur Albergaria José Luiz Marques-Rocha José Luiz Marques-Rocha Taísa Sabrina Silva Pereira Valdete Regina Guandalini Valdete Regina Guandalini |
| author_sort | Patricia Paula da Fonseca Grili |
| collection | DOAJ |
| description | BackgroundOsteoporosis is a skeletal disease characterized by reduced bone mineral density (BMD), which increases the risk of falls and fractures and reduces mobility. Some nutrients have a well-established role in maintaining bone health and preventing osteoporosis, while selenium (Se) has aroused interest in bone health possibly because of its anti-inflammatory and antioxidant capacity. The aim of this study was to evaluate the association between dietary Se consumption and BMD in postmenopausal women.Materials and methodsCross-sectional, observational, analytical study carried out with women in menopause for at least 12 months, aged ≥ 50 years. Sociodemographic, lifestyle, and clinical data variables were studied. BMD was assessed using Dual Energy X-ray Absorptiometry (DXA) and the participants classified as having normal BMD, osteopenia, or osteoporosis. Dietary consumption of Se was assessed by the food frequency questionnaire (FFQ) and classified into quartiles of consumption. Multivariate logistic regression with three fit models was applied to investigate the association of BMD with Se consumption quartiles. The significance level adopted for all tests was 5.0%.ResultsThe final sample consisted of 124 women aged in average 66.8 ± 6.1 years and with a time since menopause of 19.6 ± 8.8 years. According to the BMD, 41.9% of the women had osteopenia and 36.3% osteoporosis. The mean consumption of Se was 154.4 ± 88.7 μg/day. The highest consumption of Se was observed among women with normal BMD (51.9%), whereas lower consumption levels were found in 57.7% of women with osteopenia and in 60.0% of women with osteoporosis (p = 0.003). In the multivariate analysis, after adjusting for possible confounding variables, Se remained associated with the group of women with osteoporosis. Postmenopausal women in the highest quartile (≥94.0 μg/day) of Se consumption had an OR of 0.02 (95%CI: 0.001–0.41; p = 0.012) of having osteoporosis when compared with women in the lowest quartile.ConclusionSe consumption was associated with BMD and postmenopausal women with higher Se consumption were less likely to have osteoporosis. |
| first_indexed | 2024-04-12T22:59:26Z |
| format | Article |
| id | doaj.art-b5ca31d04ffd4d0fac842a4d2f1e52fb |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T22:59:26Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-b5ca31d04ffd4d0fac842a4d2f1e52fb2022-12-22T03:13:05ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-09-01910.3389/fnut.2022.997414997414Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal womenPatricia Paula da Fonseca Grili0Camila Vilarinho Vidigal1Geise Ferreira da Cruz2Ben Hur Albergaria3José Luiz Marques-Rocha4José Luiz Marques-Rocha5Taísa Sabrina Silva Pereira6Valdete Regina Guandalini7Valdete Regina Guandalini8Postgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, BrazilDepartment of Integrated Education, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, BrazilDepartment of Social Medicine, Federal University of Espirito Santo, Vitória, Espirito Santo, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, BrazilDepartment of Integrated Education, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, BrazilDepartment of Health Science, University of the Americas Puebla, Cholula, MexicoPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, BrazilDepartment of Integrated Education, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, BrazilBackgroundOsteoporosis is a skeletal disease characterized by reduced bone mineral density (BMD), which increases the risk of falls and fractures and reduces mobility. Some nutrients have a well-established role in maintaining bone health and preventing osteoporosis, while selenium (Se) has aroused interest in bone health possibly because of its anti-inflammatory and antioxidant capacity. The aim of this study was to evaluate the association between dietary Se consumption and BMD in postmenopausal women.Materials and methodsCross-sectional, observational, analytical study carried out with women in menopause for at least 12 months, aged ≥ 50 years. Sociodemographic, lifestyle, and clinical data variables were studied. BMD was assessed using Dual Energy X-ray Absorptiometry (DXA) and the participants classified as having normal BMD, osteopenia, or osteoporosis. Dietary consumption of Se was assessed by the food frequency questionnaire (FFQ) and classified into quartiles of consumption. Multivariate logistic regression with three fit models was applied to investigate the association of BMD with Se consumption quartiles. The significance level adopted for all tests was 5.0%.ResultsThe final sample consisted of 124 women aged in average 66.8 ± 6.1 years and with a time since menopause of 19.6 ± 8.8 years. According to the BMD, 41.9% of the women had osteopenia and 36.3% osteoporosis. The mean consumption of Se was 154.4 ± 88.7 μg/day. The highest consumption of Se was observed among women with normal BMD (51.9%), whereas lower consumption levels were found in 57.7% of women with osteopenia and in 60.0% of women with osteoporosis (p = 0.003). In the multivariate analysis, after adjusting for possible confounding variables, Se remained associated with the group of women with osteoporosis. Postmenopausal women in the highest quartile (≥94.0 μg/day) of Se consumption had an OR of 0.02 (95%CI: 0.001–0.41; p = 0.012) of having osteoporosis when compared with women in the lowest quartile.ConclusionSe consumption was associated with BMD and postmenopausal women with higher Se consumption were less likely to have osteoporosis.https://www.frontiersin.org/articles/10.3389/fnut.2022.997414/fullmenopauseosteopenianutrientsdietary intakebone mineral density |
| spellingShingle | Patricia Paula da Fonseca Grili Camila Vilarinho Vidigal Geise Ferreira da Cruz Ben Hur Albergaria José Luiz Marques-Rocha José Luiz Marques-Rocha Taísa Sabrina Silva Pereira Valdete Regina Guandalini Valdete Regina Guandalini Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women Frontiers in Nutrition menopause osteopenia nutrients dietary intake bone mineral density |
| title | Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women |
| title_full | Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women |
| title_fullStr | Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women |
| title_full_unstemmed | Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women |
| title_short | Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women |
| title_sort | dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women |
| topic | menopause osteopenia nutrients dietary intake bone mineral density |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.997414/full |
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