Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-1/Smad signaling activity in diabetic patients complicated with pulmonary infection
Objective To investigate adipocytokine expression levels, platelet-to-lymphocyte ratio (PLR) and transforming growth factor (TGF)-β1/Smad signaling activity in diabetic patients with pulmonary infection. Methods Eighty-two type 2 diabetic patients with pulmonary infection were included in the observ...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-06-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520926006 |
| _version_ | 1819032830639865856 |
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| author | Mei Zha Xiao-Bing Ren Jing Chen Ying Fang Ping Yu Yan-Yin Liu Gang Wang Jun Luo Jing Yang Ting-Wei Gou |
| author_facet | Mei Zha Xiao-Bing Ren Jing Chen Ying Fang Ping Yu Yan-Yin Liu Gang Wang Jun Luo Jing Yang Ting-Wei Gou |
| author_sort | Mei Zha |
| collection | DOAJ |
| description | Objective To investigate adipocytokine expression levels, platelet-to-lymphocyte ratio (PLR) and transforming growth factor (TGF)-β1/Smad signaling activity in diabetic patients with pulmonary infection. Methods Eighty-two type 2 diabetic patients with pulmonary infection were included in the observation group and 75 patients with simple type 2 diabetes were recruited into the control group. The fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and PLR in the two groups were compared. Complement-C1q/tumor necrosis factor related protein 3 (CTRP-3), complement-C1q/tumor necrosis factor related protein 9 (CTRP-9), leptin, adiponectin, and TGF-β1/Smad signaling pathway activity in peripheral blood mononuclear cells (PBMCs) was detected. Results Compared with patients in the control group, patients in the observation group presented with increased levels of FGB, HbA1c, and leptin, an increase in the PLR, and decreased serum CTRP-3, CTRP-9, and adiponectin levels. TGF-β1, p-Smad2, and p-Smad3 protein expression levels were up-regulated in PBMCs from patients in the observation group compared with the control group. Conclusions These results show that in type 2 diabetic patients with pulmonary infection, adipocytokine expression is altered, PLR is disturbed, and the TGF-β1/Smad signaling pathways in PBMCs are significantly activated. |
| first_indexed | 2024-12-21T07:08:11Z |
| format | Article |
| id | doaj.art-b5caba2569ca4839b8a07f8dea10dcc8 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-21T07:08:11Z |
| publishDate | 2020-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-b5caba2569ca4839b8a07f8dea10dcc82022-12-21T19:12:03ZengSAGE PublishingJournal of International Medical Research1473-23002020-06-014810.1177/0300060520926006Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-1/Smad signaling activity in diabetic patients complicated with pulmonary infectionMei ZhaXiao-Bing RenJing ChenYing FangPing YuYan-Yin LiuGang WangJun LuoJing YangTing-Wei GouObjective To investigate adipocytokine expression levels, platelet-to-lymphocyte ratio (PLR) and transforming growth factor (TGF)-β1/Smad signaling activity in diabetic patients with pulmonary infection. Methods Eighty-two type 2 diabetic patients with pulmonary infection were included in the observation group and 75 patients with simple type 2 diabetes were recruited into the control group. The fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and PLR in the two groups were compared. Complement-C1q/tumor necrosis factor related protein 3 (CTRP-3), complement-C1q/tumor necrosis factor related protein 9 (CTRP-9), leptin, adiponectin, and TGF-β1/Smad signaling pathway activity in peripheral blood mononuclear cells (PBMCs) was detected. Results Compared with patients in the control group, patients in the observation group presented with increased levels of FGB, HbA1c, and leptin, an increase in the PLR, and decreased serum CTRP-3, CTRP-9, and adiponectin levels. TGF-β1, p-Smad2, and p-Smad3 protein expression levels were up-regulated in PBMCs from patients in the observation group compared with the control group. Conclusions These results show that in type 2 diabetic patients with pulmonary infection, adipocytokine expression is altered, PLR is disturbed, and the TGF-β1/Smad signaling pathways in PBMCs are significantly activated.https://doi.org/10.1177/0300060520926006 |
| spellingShingle | Mei Zha Xiao-Bing Ren Jing Chen Ying Fang Ping Yu Yan-Yin Liu Gang Wang Jun Luo Jing Yang Ting-Wei Gou Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-1/Smad signaling activity in diabetic patients complicated with pulmonary infection Journal of International Medical Research |
| title | Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-1/Smad signaling activity in diabetic patients complicated with pulmonary infection |
| title_full | Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-1/Smad signaling activity in diabetic patients complicated with pulmonary infection |
| title_fullStr | Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-1/Smad signaling activity in diabetic patients complicated with pulmonary infection |
| title_full_unstemmed | Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-1/Smad signaling activity in diabetic patients complicated with pulmonary infection |
| title_short | Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-1/Smad signaling activity in diabetic patients complicated with pulmonary infection |
| title_sort | adipocytokine expression platelet to lymphocyte ratio and tgf 1 smad signaling activity in diabetic patients complicated with pulmonary infection |
| url | https://doi.org/10.1177/0300060520926006 |
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